De Virgiliis S, Argiolu F, Rais M, Cossu P, Toccafondi C, Sanna G, Cornacchia G, Nucaro A, Bertolino F, Ferreli A
Helv Paediatr Acta. 1983 Aug;38(3):255-65.
We report the results of a two-year non randomized prednisolone trial carried out in 18 thalassemia major patients with chronic active hepatitis and in 16 controls. We found a beneficial effect on the biochemical remission rate and on the extent of liver inflammation with no significant side effects and no overt reactivation of possible latent HBV infection at three-year follow-up. However, a more prolonged longitudinal study is necessary in order to evaluate whether steroid treatment can impede the evolution to cirrhosis without determining long-term consequences, depending on virus-host interactions such as liver cell carcinoma.
我们报告了一项针对18例重型地中海贫血合并慢性活动性肝炎患者及16例对照者进行的为期两年的泼尼松龙非随机试验结果。我们发现，在三年随访期内，该药物对生化缓解率和肝脏炎症程度有有益影响，且无明显副作用，也未出现可能潜伏的乙肝病毒感染的明显再激活情况。然而，有必要开展一项更长时间的纵向研究，以评估类固醇治疗是否能够在不产生诸如肝细胞癌等取决于病毒与宿主相互作用的长期后果的情况下，阻止病情发展为肝硬化。
