van Muijen G N, te Velde J, Willemze R, Zwaan F E, Warnaar S O
J Cancer Res Clin Oncol. 1982;104(1-2):145-54. doi: 10.1007/BF00402062.
A DNA polymerase present in particles with a density greater than 1.20 g/cm3 and capable of using a synthetic RNA template has been sought in human malignancies. This report deals with a study of a great number of peripheral-blood samples from normal controls and patients with malignant and non-neoplastic haematological disorders. For screening purposes a simplified detection test was used. In 63 controls low levels of enzyme activity were found. The enzyme activities showed a biphasic distribution pattern. Three out of 53 patients with non-neoplastic, miscellaneous haematological disorders had an elevated enzyme level associated with active viral infections (hepatitis, mononucleosis infectiosa). In 128 patients suffering from haematological malignancies 18 out of 21 cases of elevated enzyme level were associated with the presence of more than 10% pathological cells in the white blood cell fraction.
人们一直在人类恶性肿瘤中寻找一种存在于密度大于1.20 g/cm³的颗粒中且能够使用合成RNA模板的DNA聚合酶。本报告涉及对大量来自正常对照以及患有恶性和非肿瘤性血液系统疾病患者的外周血样本的研究。为了进行筛查，使用了一种简化的检测试验。在63名对照中发现了低水平的酶活性。酶活性呈现出双相分布模式。53名患有非肿瘤性、杂类血液系统疾病的患者中有3名酶水平升高，这与活动性病毒感染（肝炎、传染性单核细胞增多症）有关。在128名血液系统恶性肿瘤患者中，21例酶水平升高的病例中有18例与白细胞部分中超过10%的病理性细胞的存在有关。
