Development and properties of malignant lymphoma induced by magnesium deficiency in rats.
作者信息
Averdunk R, Bippus P H, Günther T, Merker H J
出版信息
J Cancer Res Clin Oncol. 1982;104(1-2):63-73. doi: 10.1007/BF00402054.
Abstract
Female wistar rats were fed on an Mg-deficient diet. After 8 to 10 weeks, the thymus glands were strongly degenerated and the number of lymphocytes was reduced, especially in the cortex. Thymus degeneration was associated with a decreased rate of DNA, RNA, and protein biosynthesis and necrosis and phagocytosis of lymphocytes. The degeneration was normalized after feeding on an Mg-rich diet. After 10 or 11 weeks of Mg deficiency, local cell proliferations of immature lymphocytes with a great number of free ribosomes were found in some thymus glands. The local cell proliferations developed into infiltrating tumors without metastases. In lymphoma cells the Na+ and Ca2+ content, the turnover of cellular Na+ and K+, and the aerobic production of CO2 and lactate were increased.
摘要
相似文献
1
Development and properties of malignant lymphoma induced by magnesium deficiency in rats.
J Cancer Res Clin Oncol. 1982;104(1-2):63-73. doi: 10.1007/BF00402054.
2
[Effects of kidney-tonifying Chinese herbs on thymus regene-ration after rapamycin-induced degeneration in mice].
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2025 May 25;54(3):318-332. doi: 10.3724/zdxbyxb-2024-0700.
3
Bisphosphonates for breast cancer.
Cochrane Database Syst Rev. 2005 Jul 20(3):CD003474. doi: 10.1002/14651858.CD003474.pub2.
4
Folic acid with or without vitamin B12 for cognition and dementia.
Cochrane Database Syst Rev. 2003(4):CD004514. doi: 10.1002/14651858.CD004514.
5
[Evaluation of the combined effect of platensis biomass phycyanin concentrate and soy protein on male Wistar rats fed a high-fat diet with added cholesterol].
Vopr Pitan. 2025;94(2):73-84. doi: 10.33029/0042-8833-2025-94-2-73-84. Epub 2025 Mar 19.
6
The quantity, quality and findings of network meta-analyses evaluating the effectiveness of GLP-1 RAs for weight loss: a scoping review.
Health Technol Assess. 2025 Jun 25:1-73. doi: 10.3310/SKHT8119.
7
[Protective аction of ginseng root extract on myofibril apoptosis and immune response in rats after exhausting physical exercise. Part II. Effect of ginseng root extract on immunity and regulation of energy metabolism].
Vopr Pitan. 2025;94(2):61-72. doi: 10.33029/0042-8833-2025-94-2-61-72. Epub 2025 Mar 9.
8
Magnesium protects against anaphylactic shock and cardiac myolysis in guinea-pigs.
J Basic Clin Physiol Pharmacol. 1994 Jan-Mar;5(1):45-58.
9
A Case of Idiopathic Follicular Mucinosis Treated Successfully with Cyclosporine.
Acta Dermatovenerol Croat. 2024 Dec;32(4):210-211.
10
Mg-Zn-Ca Alloy (ZX00) Screws Are Resorbed at a Mean of 2.5 Years After Medial Malleolar Fracture Fixation: Follow-up of a First-in-humans Application and Insights From a Sheep Model.
Clin Orthop Relat Res. 2024 Jan 1;482(1):184-197. doi: 10.1097/CORR.0000000000002799. Epub 2023 Aug 21.
引用本文的文献
1
Analysis of redox status and HDL subclasses in patients with lymphoma and the associations with FDG-PET/CT findings.
Front Oncol. 2023 Oct 30;13:1221414. doi: 10.3389/fonc.2023.1221414. eCollection 2023.
2
A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis.
Int J Mol Sci. 2020 Sep 25;21(19):7084. doi: 10.3390/ijms21197084.
3
Magnesium and lymphoma: opportunities in translation.
Leukemia. 2014 Apr;28(4):729-31. doi: 10.1038/leu.2013.327.
4
Enzyme histochemistry of malignant T cell lymphoma due to chronic magnesium deficiency in rats.
Histochemistry. 1984;80(2):183-6. doi: 10.1007/BF00679994.
5
Enzymatic and morphological response of the thymus to drugs in normal and zinc-deficient pregnant rats and their fetuses.
Histochemistry. 1987;86(3):321-9. doi: 10.1007/BF00490266.
6
Chronic changes in the brain Mg2+ concentration after forebrain ischemia in the rat.
Metab Brain Dis. 1991 Dec;6(4):199-206. doi: 10.1007/BF00996919.
本文引用的文献
1
Characterization of the concanavalin A-induced increase in lymphocyte cell membrane permeability by furosemide.
Immunobiology. 1980 Dec;157(4-5):358-64. doi: 10.1016/S0171-2985(80)80005-2.
2
Serum stimulation of potassium fluxes, ouabain binding, and sodium fluxes in quiescent chicken embryo fibroblasts.
J Cell Physiol. 1980 May;103(2):363-70. doi: 10.1002/jcp.1041030222.
3
Effect of concanavaline A on intracellular K+ and Na+ concentration and K+ transport of human lymphocytes.
Immunobiology. 1980 Jul;157(2):132-44. doi: 10.1016/s0171-2985(80)80095-7.
4
Intracellular concentration of sodium and other elements as related to mitogenesis and oncogenesis in vivo.
Cancer Res. 1980 May;40(5):1493-500.
5
Respiratory and calcium transport functions of mitochondria isolated from normal and transformed human lymphocytes.
Cancer Res. 1980 Feb;40(2):221-4.
6
Calcium and A23187-induced cytolysis of mouse thymocytes.
Biochem Biophys Res Commun. 1980 Mar 28;93(2):385-91. doi: 10.1016/0006-291x(80)91088-8.
7
Thymosin: basic properties and clinical application in the treatment of immunodeficiency diseases and cancer.
Recent Results Cancer Res. 1980;75:100-5. doi: 10.1007/978-3-642-81491-4_16.
8
Effect of magnesium-dependent cell membrane alterations on the transport of K+ in Ehrlich ascites tumour cells.
Acta Biol Med Ger. 1980;39(2-3):177-84.
9
A study of thymic lymphosarcoma developing in magnesium-deficient rats.
Cancer Res. 1969 Apr;29(4):763-75.
10
Serum immunoglobulin G in the magnesium-depleted rat.
Proc Soc Exp Biol Med. 1974 Mar;145(3):855-8. doi: 10.3181/00379727-145-37910.
Zotero 插件