Solleveld H A, van Zwieten M J, Zurcher C, Hollander C F
J Gerontol. 1982 Nov;37(6):656-65. doi: 10.1093/geronj/37.6.656.
This histopathological study shows that Mastomys develops a wide variety of neoplastic and nonneoplastic lesions with age. In comparing neoplastic lesions of Mastomys with those generally found in mice and rats, Mastomys is more or less unique with respect to the development of lymphoepithelial thymomas (40%), parathyroid adenomas (11%), prostatic adenocarcinomas (5%), and gastric carcinoids (4%) and the absence of brain, lung, and mammary tumors. Of the nonneoplastic lesions, prostatic (38%), thymic (12%) and parathyroid (11%) hyperplasia, and moderate to severe generalized degenerative joint disease (96%) occur rarely in mice and rats. Within the limits of this study, in which the age of the animals ranged from 18 to 39 months, a clear-cut age-related pattern was seldom found for most of the lesions occurring in Mastomys.
这项组织病理学研究表明，随着年龄增长，非洲巨鼠会出现多种肿瘤性和非肿瘤性病变。将非洲巨鼠的肿瘤性病变与通常在小鼠和大鼠中发现的病变进行比较，非洲巨鼠在淋巴上皮性胸腺瘤（40%）、甲状旁腺瘤（11%）、前列腺腺癌（5%）和胃类癌（4%）的发生方面或多或少具有独特性，并且没有脑、肺和乳腺肿瘤。在非肿瘤性病变中，前列腺（38%）、胸腺（12%）和甲状旁腺（11%）增生以及中度至重度全身性退行性关节疾病（96%）在小鼠和大鼠中很少发生。在本研究范围内，动物年龄在18至39个月之间，在非洲巨鼠中出现的大多数病变很少发现明确的年龄相关模式。
