Beucher F, Charreire J
Immunol Lett. 1983;7(2):99-106. doi: 10.1016/0165-2478(83)90041-x.
Recent studies have suggested that Praomys (Mastomys) natalensis might be a suitable model for analyzing the underlying mechanisms of autoimmunity, since a high incidence of autoantibodies to a wide variety of specificities occurs in this rodent which is intermediate in size between the mouse and the rat. Mastomys, also called the "multimammate mouse" or "multimammate rat", more closely resembles the rat than the mouse as regards some anatomical traits, and differs from both common rodents as to others. Because of controversies many years ago, Mastomys was never phylogenetically classified as a genus, but remains a subgenus, designated Praomys (Mastomys) natalensis. We have attempted to determine whether immunological markers differentiated on mouse or rat lymphocytes are present on Mastomys lymphoid cells. It was demonstrated that Mastomys cells (thymus, spleen, lymph node, bone marrow) bear theta determinants of both mouse and rat, express mouse membrane Ig, and bind with anti rat Ia antigens (which cross-react with mouse specificities). Functional markers (helper or suppressor/cytotoxic functions of the mouse or rat) were never found on Mastomys lymphoid cells.
最近的研究表明，南非多乳鼠可能是分析自身免疫潜在机制的合适模型，因为在这种介于小鼠和大鼠之间大小的啮齿动物中，出现了针对多种特异性自身抗体的高发生率。多乳鼠，也被称为“多乳头小鼠”或“多乳头大鼠”，在一些解剖学特征上比小鼠更像大鼠，而在其他方面又与这两种常见啮齿动物不同。由于多年前的争议，多乳鼠在系统发育上从未被归类为一个属，而是仍然作为一个亚属，即南非多乳鼠（Praomys (Mastomys) natalensis）。我们试图确定在小鼠或大鼠淋巴细胞上区分的免疫标记是否存在于多乳鼠的淋巴细胞上。结果表明，多乳鼠细胞（胸腺、脾脏、淋巴结、骨髓）带有小鼠和大鼠的θ决定簇，表达小鼠膜免疫球蛋白，并与抗大鼠Ia抗原（与小鼠特异性交叉反应）结合。在多乳鼠淋巴细胞上从未发现功能标记（小鼠或大鼠的辅助或抑制/细胞毒性功能）。
