Harper C G, Blumbergs P C
J Neurol Neurosurg Psychiatry. 1982 Sep;45(9):838-40. doi: 10.1136/jnnp.45.9.838.
An analysis of the brain weights of 168 alcoholics showed that the mean brain weight of male alcoholics was less (p less than 0.001) than that of a normal population. Two subgroups of alcoholics were identified. Firstly, those with nutritional brain damage (Wernicke's encephalopathy, caused by vitamin B1 deficiency) and, secondly, those with brains which appeared "normal" macroscopically and microscopically. Any change in the brain weights of this second group was unlikely to be caused by nutritional damage. Both groups had abnormally low brain weights which suggests that alcohol, the factor common to both groups, is more important than nutritional deficiencies in causing brain damage and a reduction in brain weight.
对168名酗酒者脑重量的分析表明,男性酗酒者的平均脑重量低于(p<0.001)正常人群。确定了两组酗酒者。第一组是有营养性脑损伤的(韦尼克脑病,由维生素B1缺乏引起),第二组是大脑在宏观和微观上均看似“正常”的。第二组脑重量的任何变化不太可能是由营养损伤引起的。两组的脑重量均异常低,这表明两组共有的因素——酒精,在导致脑损伤和脑重量减轻方面比营养缺乏更为重要。