Honeybourne D, Dyer P A, Mohr P D
J Neurol Neurosurg Psychiatry. 1982 Sep;45(9):854-6. doi: 10.1136/jnnp.45.9.854.
A family is reported in which myasthenia gravis and thyroid disease occur over three generations. The grandmother and granddaughter have ocular myasthenia and an aunt in the second generation had generalised myasthenia gravis with a thymoma. The pattern of histocompatibility antigens (HLA) haplotypes, anti-AChR antibodies, anti-striate muscle antibodies and thyroid disease is described. The haplotype HLA-A1, B8 was found in affected members of the first and third generation but the family study showed that this was not the same haplotype because the HLA-A1, B8 haplotype in the third generation was contributed by an unaffected person marrying into the family in the second generation.
据报道,有一个家族三代人都出现了重症肌无力和甲状腺疾病。祖母和孙女患有眼肌型重症肌无力,第二代的一位阿姨患有伴有胸腺瘤的全身型重症肌无力。本文描述了组织相容性抗原(HLA)单倍型、抗乙酰胆碱受体抗体、抗横纹肌抗体及甲状腺疾病的情况。第一代和第三代的患病成员中发现了HLA - A1、B8单倍型,但家族研究表明这并非同一单倍型,因为第三代中的HLA - A1、B8单倍型是由第二代中一位未患病的家庭成员通过婚姻带入家族的。