Feltkamp T E, van den Berg-Loonen P M, Nijenhuis L E, Engelfriet C P, van Rossum A L, van Loghem J J, Oosterhuis H J
Br Med J. 1974 Jan 26;1(5899):131-3. doi: 10.1136/bmj.1.5899.131.
The serum of 100 patients with myasthenia gravis and 441 of their first-degree relatives was studied for the presence of autoantibodies against several antigens. Antibodies to skeletal muscle were present in 22% of the patients and in 2% of the relatives. Both these frequencies were significantly higher than those in matched control subjects. Also, antinuclear antibodies were present more often both in the patients and in the relatives. Typing for HL-A antigens had shown a positive correlation between HL-A 8 and myasthenia gravis which was significantly higher in women than in men. Antibodies to skeletal muscle and thymomas were found to be much rarer in HL-A 8-positive patients than in HL-A 8-negative patients; HL-A 8-positive patients acquired the disease at an earlier age.HL-A 2-positive patients more often had thymomas and antibodies to skeletal muscle than HL-A 2-negative patients; HL-A 2-positive patients acquired myasthenia gravis at a later age.The fact that the clinical aspects of the HL-A 8-negative and HL-A 2-positive patients were different from those of the HL-A 8-positive and HL-A 2-negative patients justifies the hypothesis that there are two forms of myasthenia gravis.
对100例重症肌无力患者及其441名一级亲属的血清进行了研究，以检测针对几种抗原的自身抗体。22%的患者和2%的亲属体内存在抗骨骼肌抗体。这两个频率均显著高于匹配的对照受试者。此外，患者和亲属体内抗核抗体的出现频率也更高。对HL - A抗原的分型显示，HL - A 8与重症肌无力之间呈正相关，女性的相关性显著高于男性。在HL - A 8阳性患者中，抗骨骼肌抗体和胸腺瘤的发生率远低于HL - A 8阴性患者；HL - A 8阳性患者发病年龄较早。HL - A 2阳性患者比HL - A 2阴性患者更常患有胸腺瘤和抗骨骼肌抗体；HL - A 2阳性患者患重症肌无力的年龄较晚。HL - A 8阴性和HL - A 2阳性患者的临床症状与HL - A 8阳性和HL - A 2阴性患者不同，这一事实证明了重症肌无力存在两种形式的假说。
