染发剂与非霍奇金淋巴瘤风险：一项基于旧金山湾区人群的研究
Hair-color products and risk for non-Hodgkin's lymphoma: a population-based study in the San Francisco bay area.
作者信息
Holly E A, Lele C, Bracci P M
机构信息
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, USA.
出版信息
Am J Public Health. 1998 Dec;88(12):1767-73. doi: 10.2105/ajph.88.12.1767.
OBJECTIVES
As part of a large, epidemiologic study of non-Hodgkin's lymphoma, this study investigated a possible association between use of hair-color products and non-Hodgkin's lymphoma.
METHODS
A population-based case-control study was conducted in the San Francisco Bay area. Of 4108 participants, 2544 were questioned about use of hair-color products. Control subjects were identified by use of random-digit dialing.
RESULTS
Ever use of hair-color products was reported by 56% of case and 56% of control women and 10% of case and 9% of control men. Risks were not elevated for women for use of any hair-color products. Men who ever used semipermanent hair color had slightly elevated risks for non-Hodgkin's lymphoma, with trends associated with greater lifetime frequency of use and frequency of use per year, although individual confidence intervals overlapped unity. These elevated risks were diminished with exclusive use of semipermanent products, and confidence intervals overlapped unity.
CONCLUSIONS
Integration of our results with those from experimental animal studies and other epidemiologic studies provides little convincing evidence linking non-Hodgkin's lymphoma with normal use of hair-color products in humans.
目的
作为一项关于非霍奇金淋巴瘤的大型流行病学研究的一部分，本研究调查了使用染发剂与非霍奇金淋巴瘤之间可能存在的关联。
方法
在旧金山湾区开展了一项基于人群的病例对照研究。在4108名参与者中，对2544人询问了染发剂使用情况。通过随机数字拨号确定对照对象。
结果
报告曾经使用染发剂的病例组女性和对照组女性比例均为56%，病例组男性和对照组男性比例分别为10%和9%。女性使用任何染发剂产品的风险并未升高。曾经使用半永久性染发剂的男性患非霍奇金淋巴瘤的风险略有升高，风险趋势与终身使用频率及每年使用频率相关，尽管各个置信区间与1重叠。仅使用半永久性产品时，这些升高的风险有所降低，且置信区间与1重叠。
结论
将我们的结果与实验动物研究及其他流行病学研究的结果相结合，几乎没有令人信服的证据表明人类正常使用染发剂与非霍奇金淋巴瘤有关。
Zotero 插件