Dalbey W E
Toxicology. 1982;24(1):9-14. doi: 10.1016/0300-483x(82)90058-0.
Male Syrian golden hamsters were exposed to 10 ppm of formaldehyde (H2CO) 5 times/week for lifetime. Survival of the treated animals was reduced relative to unexposed controls. No tumors were observed in histologic sections of respiratory tract tissues from either unexposed or treated animals. Only a minimal increase in hyperplastic and metaplastic areas was observed in nasal epithelium of exposed animals. However, there was evidence that H2CO could serve as a cofactor in the incidence of respiratory tumors induced by diethylnitrosamine (DEN). Animals were exposed once per week to 30 ppm H2CO (5 h/day) for lifetime. No tumors were observed in the respiratory tract of the H2CO-only control group exposed to this regimen. Hamsters receiving exposures to H2CO at 2 days prior to each of 10 weekly DEN injections had a higher number of tracheal tumors/tumor-bearing animal at autopsy than those receiving DEN alone.
雄性叙利亚金黄地鼠终生每周5次暴露于10 ppm的甲醛（H₂CO）环境中。与未暴露的对照组相比，接受处理的动物的存活率降低。在未暴露或接受处理的动物的呼吸道组织的组织学切片中均未观察到肿瘤。在暴露动物的鼻上皮中仅观察到增生和化生区域有极小的增加。然而，有证据表明H₂CO可作为二乙基亚硝胺（DEN）诱导的呼吸道肿瘤发生率的辅助因子。动物终生每周一次暴露于30 ppm H₂CO（每天5小时）。暴露于该方案的仅H₂CO的对照组的呼吸道中未观察到肿瘤。在每周10次DEN注射的每次注射前2天接受H₂CO暴露的仓鼠，在尸检时每只患瘤动物的气管肿瘤数量比仅接受DEN的仓鼠多。
