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实验性骨关节炎对雌二醇和雌二醇拮抗剂的病理及代谢反应

Pathologic and metabolic responses of experimental osteoarthritis to estradiol and an estradiol antagonist.

作者信息

Rosner I A, Malemud C J, Goldberg V M, Papay R S, Getzy L, Moskowitz R W

出版信息

Clin Orthop Relat Res. 1982 Nov-Dec(171):280-6.

PMID:7140079
Abstract

Tamoxifen, an estradiol antagonist, and estradiol were separately evaluated in a rabbit experimental osteoarthritis. Cartilage from anatomically defined regions of individual rabbit knees was assayed for sulfate and thymidine incorporation. Tamoxifen reduced erosive osteoarthritic pathology, while estradiol worsened it. There was no effect on the incidence of osteophytes. Metabolic studies in organ culture showed no changes relating to treatment. The results suggest that specific medical therapy for osteoarthritis is within the realm of possibility.

摘要

他莫昔芬,一种雌二醇拮抗剂,和雌二醇分别在兔实验性骨关节炎中进行了评估。对来自单个兔膝关节解剖学定义区域的软骨进行了硫酸盐和胸苷掺入测定。他莫昔芬减轻了侵蚀性骨关节炎病理,而雌二醇则使其恶化。对骨赘的发生率没有影响。器官培养中的代谢研究表明与治疗无关的变化。结果表明,骨关节炎的特定医学治疗是有可能的。

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