Moskowitz R W, Goldberg V M, Malemud C J
Ann Rheum Dis. 1981 Dec;40(6):584-92. doi: 10.1136/ard.40.6.584.
Serial metabolic responses in developing osteoarthritis induced in the right knees of a rabbit model of partial meniscectomy (PM) were studied. Controls were sham-operated (SH) right knees, left knees of all operated animals, nd right and left knees of a nonoperated series. Glycosaminoglycan and protein synthesis and cell replication were separately analysed utilising 35 SO4, 14C-Glycine, and 3H-thymidine, respectively. Pitting, ulceration, and osteophytes, seen only in the PM knees, increased over the 12-week period of study. 3H-thymidine and 14C-glycine incorporations by PM cartilage were increased at 3 weeks, less than nonoperated control animals at 9 weeks, and approximated to those of controls at 12 weeks. 35 SO4 incorporation by tibial osteophytes was decreased at 9 and 12 weeks. Similar isotope incorporations seen after partial meniscectomy and sham surgery represented a nonspecific response to arthrotomy. Cartilage synthetic activity did not increase in parallel with degenerative change.
研究了部分半月板切除术（PM）兔模型右膝诱导的发育性骨关节炎中的系列代谢反应。对照组为假手术（SH）右膝、所有手术动物的左膝以及未手术组的右膝和左膝。分别利用35SO4、14C-甘氨酸和3H-胸腺嘧啶核苷分析糖胺聚糖、蛋白质合成和细胞复制。仅在PM膝关节中出现的点蚀、溃疡和骨赘在12周的研究期间有所增加。PM软骨对3H-胸腺嘧啶核苷和14C-甘氨酸的摄取在3周时增加，在9周时低于未手术对照动物，在12周时接近对照组。胫骨骨赘在9周和12周时对35SO4的摄取减少。部分半月板切除术后和假手术后观察到的类似同位素摄取代表了对关节切开术的非特异性反应。软骨合成活性并未与退行性变化平行增加。
