Rosner I A, Goldberg V M, Moskowitz R W
Clin Orthop Relat Res. 1986 Dec(213):77-83.
Clinical and laboratory observations suggest that a relationship exists between sex hormones and the development of osteoarthritis. The mechanisms whereby these hormones influence the pathophysiology of osteoarthritis have been explored. Tamoxifen, an estrogen antagonist, reduced erosive changes in meniscectomy-induced osteoarthritis in rabbits. By contrast, estradiol worsened it. There was no effect of either agent on the incidence of osteophytes in this model. Both estradiol and tamoxifen affected proteoglycan, prostaglandin, and proteoglycanase production by cartilage components. These observations suggest that cartilage is a sex hormone-sensitive tissue. This may have therapeutic implications in the future.
临床和实验室观察表明，性激素与骨关节炎的发展之间存在关联。人们已经探究了这些激素影响骨关节炎病理生理学的机制。他莫昔芬是一种雌激素拮抗剂，可减少兔半月板切除诱导的骨关节炎中的侵蚀性变化。相比之下，雌二醇会使其恶化。在该模型中，这两种药物对骨赘的发生率均无影响。雌二醇和他莫昔芬均影响软骨成分产生蛋白聚糖、前列腺素和蛋白聚糖酶。这些观察结果表明，软骨是一种对性激素敏感的组织。这可能在未来具有治疗意义。
