Fabry L, Léonard A, Roberfroid M
Mutat Res. 1978 Sep;51(3):377-81. doi: 10.1016/0027-5107(78)90125-2.
The capability of styrene oxide to induce chromosome damage in vivo has been tested in the male mouse by examination of bone-marrow cells, by scoring micronuclei in polychromatic erythrocytes, by observation of meiotic chromosomes from treated males and by the dominant-lethality test. Furthermore, studies have been performed on short-term cultures of human lymphocytes in vitro. Whereas an increase in the yield of chromatid and chromosomal aberrations was observed after exposure in vitro, only negative results were obtained in the tests in vivo. One has, therefore, to conclude that styrene oxide is potentially capable of breaking mammalian chromosomes but that an exposure to an acute dose in vivo does not produce visible damage in somatic cells or in male germ cells.
通过对雄性小鼠骨髓细胞的检查、对多染性红细胞中的微核进行计数、观察经处理雄性小鼠的减数分裂染色体以及进行显性致死试验，对氧化苯乙烯在体内诱导染色体损伤的能力进行了测试。此外，还对人淋巴细胞的短期体外培养进行了研究。虽然在体外暴露后观察到染色单体和染色体畸变率增加，但体内试验仅得到阴性结果。因此，人们不得不得出结论，氧化苯乙烯可能有能力破坏哺乳动物的染色体，但体内急性剂量暴露不会在体细胞或雄性生殖细胞中产生可见损伤。
