Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
J Expo Sci Environ Epidemiol. 2013 Mar;23(2):197-206. doi: 10.1038/jes.2012.105. Epub 2012 Nov 21.
Several phthalates, particularly diethyl phthalate (DEP) and di-n-butyl phthalate, can be used in personal care products (PCPs) to fix fragrance and hold color. We investigated associations between women's reported use of PCPs within the 24 h before urine collection and concentrations of several urinary phthalate metabolites. Between 2002 and 2005, 337 women provided spot urine samples and answered questions regarding their use of 13 PCPs at a follow-up visit 3-36 months after pregnancy. We examined associations between urinary concentrations of several phthalate metabolites and use of PCPs using linear regression. Use of individual PCPs ranged from 7% (nail polish) to 91% (deodorant). After adjusting for age, education, and urinary creatinine, women reporting use of perfume had 2.92 times higher (95% CI: 2.20-3.89) concentration of monoethyl phthalate (MEP; the primary metabolite of DEP) than other women. Other PCPs that were significantly associated with MEP concentrations included: hair spray, nail polish, and deodorant. MEP concentrations increased with the number of PCPs used. PCP use was widespread in this group of recently pregnant women. Women's use of PCPs, particularly of perfumes and fragranced products, was positively associated with urinary concentration of multiple phthalate metabolites.
几种邻苯二甲酸酯，特别是邻苯二甲酸二乙酯（DEP）和邻苯二甲酸二丁酯，可用于个人护理产品（PCP）中固定香味和保持颜色。我们研究了女性在收集尿液前 24 小时内报告使用 PCP 与几种尿邻苯二甲酸代谢物浓度之间的关系。在 2002 年至 2005 年期间，337 名女性提供了点尿样，并在怀孕后 3-36 个月的随访中回答了有关其使用 13 种 PCP 的问题。我们使用线性回归检查了几种邻苯二甲酸代谢物的尿液浓度与 PCP 使用之间的关系。个别 PCP 的使用范围从 7%（指甲油）到 91%（除臭剂）。在调整年龄、教育程度和尿肌酐后，报告使用香水的女性的单乙基邻苯二甲酸酯（MEP；DEP 的主要代谢物）浓度比其他女性高 2.92 倍（95%CI：2.20-3.89）。与 MEP 浓度显著相关的其他 PCP 包括：发胶、指甲油和除臭剂。随着 PCP 使用数量的增加，MEP 浓度增加。在这群最近怀孕的女性中，PCP 的使用非常普遍。女性使用 PCP，特别是香水和香薰产品，与多种邻苯二甲酸代谢物的尿液浓度呈正相关。
