槲皮素、类黄酮与小鼠的寿命
Quercetin, flavonoids and the life-span of mice.
作者信息
Jones E, Hughes R E
出版信息
Exp Gerontol. 1982;17(3):213-7. doi: 10.1016/0531-5565(82)90027-4.
PMID:7140862
Abstract
A dietary supplement of 0.1% quercetin significantly reduced the life span of mice. The effect was predominantly on the 'shorter living' males. A blackcurrant juice extract, containing a mixture of flavonoids in addition to quercetin, prolonged significantly the life span of the 'older dying' females. The significance of these results vis-a-vis aging mechanisms and the dietary intake of quercetin is discussed.
摘要
0.1%的槲皮素膳食补充剂显著缩短了小鼠的寿命。这种影响主要体现在“寿命较短”的雄性小鼠身上。一种黑加仑汁提取物，除了含有槲皮素外还含有多种类黄酮混合物，显著延长了“年老濒死”雌性小鼠的寿命。本文讨论了这些结果对于衰老机制和槲皮素膳食摄入量的意义。
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