Beketov A I, Skoromnyĭ N A, Guk M G, Shtepa O S, Shpilevoĭ A I
Farmakol Toksikol. 1982 Sep-Oct;45(5):45-9.
It has been shown by hydrogen clearance that diprazine (1 mg/kg) given to anesthetized cats reduces the total brain blood flow and local circulation in the cortex of the frontal lobe in the presence of a decrease in arterial pressure and blood flow in the kidneys and caudal vena cava. In intact rabbits, there is an increase in the total and local circulation in the frontal and temporal lobes of the brain followed by a decrease. Diprazine-induced changes in the brain blood flow are phasic in nature and characterized by labile redistribution of the blood flow between the different brain lobes. Cerebral vascular responses to diprazine have been found to be most pronounced in intact animals.
氢清除法显示，给麻醉猫注射地普嗪（1毫克/千克）后，在动脉压、肾血流量和尾腔静脉血流量降低的情况下，大脑总血流量和额叶皮质局部循环减少。在未受损的兔子中，大脑额叶和颞叶的总循环和局部循环先增加后减少。地普嗪引起的脑血流变化具有阶段性，其特征是不同脑叶之间的血流不稳定重新分布。已发现脑血管对地普嗪的反应在未受损动物中最为明显。
