[Blood flow changes in the brain, kidneys and caudal vena cava as affected by diprazin].

It has been shown by hydrogen clearance that diprazine (1 mg/kg) given to anesthetized cats reduces the total brain blood flow and local circulation in the cortex of the frontal lobe in the presence of a decrease in arterial pressure and blood flow in the kidneys and caudal vena cava. In intact rabbits, there is an increase in the total and local circulation in the frontal and temporal lobes of the brain followed by a decrease. Diprazine-induced changes in the brain blood flow are phasic in nature and characterized by labile redistribution of the blood flow between the different brain lobes. Cerebral vascular responses to diprazine have been found to be most pronounced in intact animals.