Shadurskiĭ K S, Il'iuchenok T Iu, Samokhvalov G I, Obol'nikova E A, Gololobov A D
Farmakol Toksikol. 1982 Sep-Oct;45(5):97-101.
Experiments were made on random-bred and linear mice, Wistar rats, rabbits and dogs to examine pharmacological properties of ubiquinone-9 and hexahydroubiquinone-4. Both compounds (oily solutions) administered intraperitoneally, intragastrically and subcutaneously in single and multiple doses produced no changes in the behavior or status of the animals, which might have attested to their toxicity. They were found to exert a regulatory action on the central nervous system, decreasing its sensitivity to numerous narcotic and convulsant substances without appreciable effects on the blood, arterial pressure, ECG and diuresis. The main obstacle for comprehensive experimental study and application of these substances in medical practice lies in the absence of a perfect medicinal form.
对随机繁殖的线性小鼠、Wistar大鼠、兔子和狗进行了实验，以研究泛醌-9和六氢泛醌-4的药理特性。两种化合物（油溶液）经腹腔、胃内和皮下单剂量及多剂量给药后，动物的行为或状态均未发生变化，这可能证明它们没有毒性。发现它们对中枢神经系统有调节作用，可降低其对多种麻醉和惊厥物质的敏感性，而对血液、动脉血压、心电图和利尿没有明显影响。在医学实践中对这些物质进行全面实验研究和应用的主要障碍在于缺乏完善的药用剂型。
