Dubin N H, Blake D A, DiBlasi M C, Parmley T H, King T M
Fertil Steril. 1982 Dec;38(6):735-40. doi: 10.1016/s0015-0282(16)46703-8.
Recent efforts have been made to develop a chemical oviductal occluding agent. Intrauterine quinacrine has been used in certain areas of the world with moderate success in effected tubal closure. This report presents the pharmacokinetics of a quinacrine solution (30 mg) as administered to cynomolgus monkeys via the intrauterine route, compared with intravascular injection. The data show rapid transfer of the drug from the uterine to the vascular compartment and uptake by almost all tissues examined. Although plasma concentrations disappear within 24 hours, levels can be detected in most tissues for at least 1 week following intrauterine injection. After 28 days, however, tissue levels of the drug are absent or near the limit of detection.
最近人们致力于开发一种化学输卵管闭塞剂。在世界某些地区，子宫内使用奎纳克林在实现输卵管闭合方面取得了一定成功。本报告介绍了通过子宫内途径给食蟹猴施用的奎纳克林溶液（30毫克）的药代动力学，并与血管内注射进行了比较。数据显示药物从子宫迅速转移到血管腔，并被几乎所有检测的组织摄取。虽然血浆浓度在24小时内消失，但子宫内注射后至少1周在大多数组织中都能检测到药物水平。然而，28天后，药物的组织水平不存在或接近检测限。
