微生物相互作用对大鼠牙菌斑中粘性放线菌或变形链球菌定植率的影响。
Effect of microbial interaction on the colonization rate of Actinomyces viscosus or Streptococcus mutans in the dental plaque of rats.
作者信息
Beckers H J, van der Hoeven J S
出版信息
Infect Immun. 1982 Oct;38(1):8-13. doi: 10.1128/iai.38.1.8-13.1982.
The resident oral microflora of conventional Osborne-Mendel rats was challenged with Actinomyces viscosus or Streptococcus mutans strains. The adherence of the inoculated organism to the tooth surface and the subsequent growth were studied by means of viable counts determination. The initial growth rate of S. mutans in conventional rats was lower than in mono-associated gnotobiotic rats (doubling time, td = 5 h versus td = 1.1 h). The delayed start of growth and the low initial growth rate indicated that a competitive interaction between S. mutans and the resident microflora occurred. The initial growth rate of A. viscosus in conventional rats (td = 3.1 h) was approximately the same as that in gnotobiotic rats (td = 2.8 h). The start of growth of A. viscosus was only slightly delayed compared with the start in gnotobiotic rats. These results suggest a neutralistic relationship between A. viscosus and the resident microflora. A. viscosus reached a stationary level about 7 days after inoculation, whereas the S. mutans strains did not reach stationary levels until 2 weeks after inoculation.
用粘性放线菌或变形链球菌菌株对常规奥斯本-孟德尔大鼠的口腔常驻微生物群进行挑战。通过活菌计数测定研究接种的生物体在牙齿表面的粘附以及随后的生长情况。变形链球菌在常规大鼠中的初始生长速率低于单关联悉生大鼠（倍增时间，td = 5小时对td = 1.1小时）。生长开始延迟和初始生长速率低表明变形链球菌与常驻微生物群之间发生了竞争性相互作用。粘性放线菌在常规大鼠中的初始生长速率（td = 3.1小时）与悉生大鼠中的大致相同（td = 2.8小时）。与悉生大鼠相比，粘性放线菌的生长开始仅略有延迟。这些结果表明粘性放线菌与常驻微生物群之间存在中立关系。粘性放线菌在接种后约7天达到稳定水平，而变形链球菌菌株直到接种后2周才达到稳定水平。
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