Beckers H J, van der Hoeven J S
Arch Oral Biol. 1984;29(3):231-6. doi: 10.1016/0003-9969(84)90060-8.
The bacteria were simultaneously inoculated into the mouths of germ-free rats. The maximum growth rates attained by Strep. mutans (doubling time td = 1.4 h) or A. viscosus (td = 2.7 h) were approximately the same as in mono-associated gnotobiotic rats [td = 1.1 and 2.8 h, respectively (Beckers and van der Hoeven, 1982a)]. The presence of glucose or sucrose did not affect the maximum growth rates. In starved rats, the accumulation of microorganisms tended to decline sooner, suggesting that the growth was limited by the availability of nutrients. No interaction between the two organisms was detected at the stage of initial adherence to the tooth surfaces or during the first 24 h of growth. After that, the increase of A. viscosus was retarded in the presence of Strep. mutans T2, but not with Strep. mutans OMZ176. The retardation was more pronounced in the rats fed on glucose than on sucrose. Yet, at 24 days after inoculation. A. viscosus had increased in the glucose more than in the sucrose group. Hence sucrose did not stimulate the accumulation of Strep. mutans more than glucose.
将这些细菌同时接种到无菌大鼠的口腔中。变形链球菌（倍增时间td = 1.4小时）或黏性放线菌（td = 2.7小时）达到的最大生长速率与单定殖悉生大鼠中的大致相同[分别为td = 1.1和2.8小时（贝克斯和范德霍芬，1982a）]。葡萄糖或蔗糖的存在不影响最大生长速率。在饥饿的大鼠中，微生物的积累倾向于更快下降，这表明生长受到营养物质可用性的限制。在最初附着于牙齿表面的阶段或生长的最初24小时内，未检测到这两种生物之间的相互作用。在此之后，在变形链球菌T2存在的情况下，黏性放线菌的增加受到抑制，但在变形链球菌OMZ176存在时则不然。在以葡萄糖为食的大鼠中，这种抑制作用比以蔗糖为食的大鼠中更明显。然而，在接种后24天，黏性放线菌在葡萄糖组中的增加比在蔗糖组中更多。因此，蔗糖对变形链球菌积累的刺激作用并不比葡萄糖更强。
