Moizhess T G
Int J Cancer. 1982 Oct 15;30(4):525-9. doi: 10.1002/ijc.2910300421.
The local effect of an implanted foreign body (polyvinyl chloride film) on the growth of transplanted syngeneic sarcoma cells was studied. Two cell lines derived from CBA mouse sarcomas induced by subcutaneously implanted polymer films were used. Small numbers of tumour cells were subcutaneously transplanted to CBA mice in several ways (1) as a suspension into normal tissue (control group); (2) as a suspension into the capsules around previously implanted polymer films; (3) attached to the surface of polymer films, and implanted with these films. The incidence of tumours was significantly increased and the time of their appearance was decreased in groups (2) and (3) as compared with the control group (1). Removal of the film from the capsule 24 h after the transplantation of sarcoma cells did not abolish the stimulation of tumor growth. It is concluded that the local environment of the implanted foreign body promotes the growth of sarcoma cells; similar promoting effects may play some role in the course of foreign body tumorigenesis.
研究了植入异物（聚氯乙烯薄膜）对同基因移植肉瘤细胞生长的局部影响。使用了两种由皮下植入聚合物薄膜诱导的CBA小鼠肉瘤衍生的细胞系。将少量肿瘤细胞以几种方式皮下移植到CBA小鼠体内：（1）作为悬浮液注入正常组织（对照组）；（2）作为悬浮液注入先前植入聚合物薄膜周围的包膜中；（3）附着在聚合物薄膜表面，并与这些薄膜一起植入。与对照组（1）相比，第（2）组和第（3）组的肿瘤发生率显著增加，肿瘤出现时间缩短。肉瘤细胞移植24小时后从包膜中取出薄膜并没有消除对肿瘤生长的刺激。得出的结论是，植入异物的局部环境促进肉瘤细胞的生长；类似的促进作用可能在异物致瘤过程中起一定作用。
