Comparative study of the permeability induced by aromatic and non aromatic heptaenes on small and large lipidic vesicles.

The efficiency in inducing cation permeability of vacidin A, candicidin D and amphotericin B has been compared on small and large lipidic vesicles. Amphotericin B is two times less effective on large than on small vesicles. On the contrary, vacidin A and candicidin D are about ten times more effective on large than on small vesicles. These data are consonant with what is observed on living cells.