Mazerski J, Bolard J, Borowski E
Biochem Biophys Res Commun. 1983 Oct 31;116(2):520-6. doi: 10.1016/0006-291x(83)90554-5.
Unlike the non-aromatic heptaene amphotericin B, only two types of complex are revealed by circular dichroism when the aromatic heptaenes interact with lipid vesicles. The first is formed when no permeability is observed. The second one is correlated with the appearance of permeability. The cholesterol concentration and the physical state of the membrane have influence only on the amount of the permeabilizing species. These results indicate important differences in the membrane properties of aromatic and non-aromatic heptaenes.
与非芳香族七烯两性霉素B不同，当芳香族七烯与脂质囊泡相互作用时，圆二色性仅揭示出两种复合物类型。第一种是在未观察到通透性时形成的。第二种与通透性的出现相关。胆固醇浓度和膜的物理状态仅对通透物种的数量有影响。这些结果表明芳香族和非芳香族七烯在膜性质上存在重要差异。
