多烯大环内酯类抗生素真菌色素、拉戈辛和可哥霉素的物理化学及生物学比较

Physicochemical and biological comparison of polyene macrolide antibiotics fungichromin, lagosin and cogomycin.

作者信息

Pandey R C, Guenther E C, Aszalos A A, Brajtburg J

出版信息

J Antibiot (Tokyo). 1982 Aug;35(8):988-96. doi: 10.7164/antibiotics.35.988.

DOI:10.7164/antibiotics.35.988

PMID:7142017

Abstract

The three polyene macrolide antibiotics, fungichromin, lagosin, and cogomycin, previously described as having some stereochemical differences at one or more centers, are shown by countercurrent distribution, high-performance liquid chromatography, carbon-13 nuclear magnetic resonance spectroscopy, circular dichroism, and biological studies to be identical in all respects, including stereochemical aspects. The differences observed earlier in their properties have now been ascribed to varying amounts of impurities, which are separable by high-performance liquid chromatography. All three antibiotics contain one major and several minor components.

摘要

之前描述的三种多烯大环内酯类抗生素，即真菌色素、拉戈辛和可戈霉素，在一个或多个中心具有一些立体化学差异，通过逆流分配、高效液相色谱、碳-13核磁共振光谱、圆二色性和生物学研究表明，它们在所有方面都是相同的，包括立体化学方面。早期观察到的它们性质上的差异现在归因于不同量的杂质，这些杂质可通过高效液相色谱分离。所有三种抗生素都含有一种主要成分和几种次要成分。