Evans C H, Mears D C, Stanitski C L
J Bone Joint Surg Br. 1982;64(5):572-8. doi: 10.1302/0301-620X.64B5.7142265.
Ferrography is a technique for analysing wear by means of the magnetic separation of wear particles. To evaluate its application in human joints, the results of the ferrographic analysis of saline washings of symptomatic human knees were compared with the results of the arthroscopic examination of the same knees. Ferrography was found to be an extremely sensitive monitor of articular erosion, with a resolution far greater than that of arthroscopy. This was particularly apparent with knees suffering from a torn anterior cruciate ligament: arthroscopy detected no damage to the cartilaginous surfaces whereas ferrography detected a substantial level of "microdamage". The spectrum of wear particles showed qualitative and quantitative alterations depending upon the condition of the knee. Ferrography thus holds much promise as a potential differential diagnostic technique of great sensitivity, with particular relevance to the very early changes which precede clinical symptoms. Study of wear particles is also justified by evidence indicating an active role in the pathophysiological progression of arthritis.
铁谱分析技术是一种通过对磨损颗粒进行磁分离来分析磨损情况的技术。为评估其在人体关节中的应用，将有症状的人类膝关节盐水冲洗液的铁谱分析结果与同一膝关节的关节镜检查结果进行了比较。结果发现，铁谱分析是一种对关节侵蚀极其敏感的监测方法，其分辨率远高于关节镜检查。这在患有前交叉韧带撕裂的膝关节中尤为明显：关节镜检查未发现软骨表面有损伤，而铁谱分析检测到了大量的“微损伤”。磨损颗粒的光谱显示出定性和定量的变化，这取决于膝关节的状况。因此，铁谱分析作为一种具有高度敏感性的潜在鉴别诊断技术，具有很大的前景，尤其适用于临床症状出现之前的早期变化。有证据表明磨损颗粒在关节炎的病理生理进展中发挥着积极作用，因此对磨损颗粒的研究也是合理的。
