Burrows G E, Liu D H, Isom G E, Way J L
J Toxicol Environ Health. 1982 Aug;10(2):181-9. doi: 10.1080/15287398209530242.
Attempts were made to evaluate the effects of pretreatment with air and oxygen either alone or in various combinations with sodium nitrite and/or sodium thiosulfate on the physiological disposition of 14C-labeled sodium cyanide in mice. The radioactive respiratory excretion was studied by radiorespirometry, and the effects of various combinations of cyanide antagonists were compared. Oxygen either alone or in combination with sodium thiosulfate significantly enhanced the respiratory excretion when compared with air. Sodium thiosulfate accelerated the initial rate, but not the total amount of radioactivity excreted. The cumulative recovery of radioactive gases was significantly greater with groups receiving oxygen either alone or with sodium thiosulfate. When sodium nitrite was employed as an antidote either alone or with sodium thiosulfate, no difference in the respiratory excretion was noted between air and oxygen. The use of the sodium nitrite-sodium thiosulfate combination either with air or oxygen resulted in a marked decrease in the initial rate as well as the total amount of respiratory radioactivity excreted. No significant differences between various experimental groups were noted in the total amount of urinary radioactivity excreted or the total body retention of radioactivity.
研究人员尝试评估单独使用空气和氧气预处理，以及空气和氧气与亚硝酸钠和/或硫代硫酸钠的各种组合预处理对小鼠体内14C标记氰化钠生理分布的影响。通过放射性呼吸测定法研究放射性呼吸排泄，并比较氰化物拮抗剂各种组合的效果。与空气相比，单独使用氧气或氧气与硫代硫酸钠联合使用均能显著增强呼吸排泄。硫代硫酸钠加快了初始排泄速率，但不影响放射性物质的总排泄量。单独使用氧气或氧气与硫代硫酸钠联合使用的组中，放射性气体的累积回收率显著更高。单独使用亚硝酸钠或亚硝酸钠与硫代硫酸钠联合用作解毒剂时，空气组和氧气组在呼吸排泄方面未观察到差异。亚硝酸钠与硫代硫酸钠联合使用，无论与空气还是氧气组合，均导致初始排泄速率以及呼吸放射性物质的总排泄量显著降低。各实验组在尿中放射性物质的总排泄量或全身放射性物质滞留量方面未观察到显著差异。
