Turski L, Schwarz M, Sontag K H
Naunyn Schmiedebergs Arch Pharmacol. 1982 Oct;321(1):48-51. doi: 10.1007/BF00586348.
The muscle relaxant (antispastic) effect of diazepam, alone or in combination with phenytoin, was studied in mutant Han-Wistar rats with progressive spastic paresis. Alone, phenytoin did not alter the spontaneous activity in the electromyogram (EMG) of the gastrocnemius soleus (GS) muscle of mutant rats, but strongly enhanced the depressant action of diazepam on the spontaneous EMG activity. Picrotoxin reduced the antispastic effect of diazepam alone and partially reversed the antispastic effect of combined treatment. Therefore, the antagonistic effect of picrotoxin on the reduction of the spontaneous activity in the EMG produced by the combination of both drugs hardly suggests an interaction of picrotoxin with phenytoin, but rather indicates an interaction with the effect of diazepam. Phenytoin enhancement of the depressant action of diazepam on the spontaneous EMG activity of mutant rats strongly suggests the potential therapeutic usefulness of the combined treatment with both drugs.
在患有进行性痉挛性麻痹的突变型Han-Wistar大鼠中，研究了地西泮单独使用或与苯妥英联合使用时的肌肉松弛（抗痉挛）作用。单独使用时，苯妥英不会改变突变型大鼠腓肠肌比目鱼肌（GS）的肌电图（EMG）中的自发活动，但会强烈增强地西泮对自发EMG活动的抑制作用。印防己毒素会降低地西泮单独使用时的抗痉挛作用，并部分逆转联合治疗的抗痉挛作用。因此，印防己毒素对两种药物联合使用所产生的EMG自发活动减少的拮抗作用，几乎不能表明印防己毒素与苯妥英之间存在相互作用，而更表明其与地西泮的作用存在相互作用。苯妥英增强地西泮对突变型大鼠自发EMG活动的抑制作用，强烈表明两种药物联合治疗具有潜在的治疗用途。
