Shaver J F
Nurse Pract. 1982 Oct;7(9):15-9.
In response to threat, particularly the invasion of microorganisms, body temperature rises, a condition called fever. This occurs as phagocytic cells in the body are activated to secrete substances which generate a multitude of host defense responses. Evidence is presented that this response is likely adaptive for the individual and fever acts to synergistically support the responses. Implications for practice are that the attenuation of fever by clinical interventions could limit the defense mechanisms for the individual and a more effective therapeutic goal might be to keep body temperature within certain limits. Developing knowledge about the host defense response and fever mechanisms will suggest supportive therapeutic options for testing.
作为对威胁，尤其是微生物入侵的反应，体温会升高，这种情况称为发热。当体内的吞噬细胞被激活以分泌产生多种宿主防御反应的物质时，就会发生这种情况。有证据表明，这种反应可能对个体具有适应性，发热起到协同支持这些反应的作用。对实践的启示是，临床干预对发热的抑制可能会限制个体的防御机制，更有效的治疗目标可能是将体温保持在一定范围内。对宿主防御反应和发热机制的深入了解将为测试提供支持性的治疗选择。
