Kahn A, Blum D, Waterschoot P, Engelman E, Smets P
Pediatrics. 1982 Dec;70(6):852-7.
In order to investigate the effects of obstructive sleep apneas upon transcutaneous PO2 75 polysomnograms, recorded during night sessions in 25 control infants, 25 siblings, and 25 near miss for sudden infant death syndrome (SIDS) infants were studied. These observations were compared with the decreases in transcutaneous PO2 measured during central sleep apneas in the same infants. During a total of 707.6 hours of sleep, 33 obstructive apneas and 1,650 central apneas were recorded. Obstructive apneas were seen in three control infants (three episodes), one sibling (five episodes), and six near miss for SIDS infants (25 episodes). The obstructive apneas tended to be short (less than 10 seconds). Comparatively, the central apneas were equally distributed in the three groups of infants, and only the near miss children presented apneas that lasted as long as 19 seconds. The decrease in transcutaneous PO2 was proportional to the duration of both types of apnea, but for a given duration the decrease in transcutaneous PO2 was significantly greater for the obstructive apneas than for the central apneas (with a mean difference of 7.59 +/- 0.53% PO2. It is concluded that the hypoxic effects of the obstructive apneas might have important clinical implications in infants, such as the near miss for SIDS.
为了研究阻塞性睡眠呼吸暂停对经皮血氧分压（PO₂）的影响，我们对25名对照婴儿、25名同胞婴儿和25名婴儿猝死综合征（SIDS）高危婴儿夜间睡眠期间记录的75份多导睡眠图进行了研究。将这些观察结果与同一婴儿中枢性睡眠呼吸暂停期间测得的经皮PO₂下降情况进行比较。在总共707.6小时的睡眠中，记录到33次阻塞性呼吸暂停和1650次中枢性呼吸暂停。在3名对照婴儿（3次发作）、1名同胞婴儿（5次发作）和6名SIDS高危婴儿（25次发作）中观察到阻塞性呼吸暂停。阻塞性呼吸暂停往往较短（少于10秒）。相比之下，中枢性呼吸暂停在三组婴儿中分布均匀，只有高危婴儿出现长达19秒的呼吸暂停。经皮PO₂的下降与两种类型呼吸暂停的持续时间成正比，但在给定持续时间内，阻塞性呼吸暂停导致的经皮PO₂下降明显大于中枢性呼吸暂停（平均差异为7.59±0.53%PO₂）。得出的结论是，阻塞性呼吸暂停的缺氧效应可能对婴儿有重要的临床意义，如SIDS高危情况。
