抗炎吲哚对膜的稳定作用及对脂质过氧化的抑制作用
Membrane stabilization and inhibition of lipid peroxidation by anti-inflammatory indoles.
作者信息
Kaur S, Ali B
出版信息
Pharmacology. 1982;25(4):210-3. doi: 10.1159/000137744.
PMID:7146086
Abstract
Nine 2-aryl-3-[4-(substituted phenyl)-3-thiosemicarbazone] indoles were evaluated for their ability to protect the human erythrocyte membrane against hypo-osmotic hemolysis and inhibit lipid peroxidation in rat liver homogenate in vitro. All compounds caused membrane stabilization and inhibition of lipid peroxidation when tested at final concentrations of 5 X 10(-4) and 2.5 X 10(-5) mol/l, respectively. These biochemical effects were not related to the anti-inflammatory property exhibited by the compounds.
摘要
评估了九种2-芳基-3-[4-(取代苯基)-3-硫代氨基脲]吲哚保护人红细胞膜免受低渗溶血以及在体外抑制大鼠肝匀浆脂质过氧化的能力。当分别以5×10⁻⁴和2.5×10⁻⁵ mol/l的终浓度进行测试时，所有化合物均引起膜稳定并抑制脂质过氧化。这些生化效应与化合物所表现出的抗炎特性无关。
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