Simon P, Menault M, Tanquerel T, Herry D
Nouv Presse Med. 1978 Sep 23;7(32):2837-40.
Twelve patients on haemodialysis for 6 months to 3 years contracted AgHBs positive hepatitis, 9 being also Ag e positive. They continued to carry the same antigens. Histological surveillance was begun from the 6th month of the disease onwards, with 2 to 4 repeated biopsies in 1,5 to 3,5 years in 9 patients, the last 3 having only one biopsy between the 8th and the 15th month. In 6 patients, the first biopsy revealed chronic persistent hepatitis (CPH) and in other 6 (5 male and 1 female) chronic aggressive hepatitis (CAH). Subsequent biopsies revealed cirrhosis in a patient treated with alphamethyldopa (Ag e +), the absence of any changes in 7 other patients (4 CPH including 3 Ag e + and 3 CAH including 2 Ag e +), and an improvement in the last. Long term surveillance of hepatitis B by repeated biopsies in haemodialysed patients reveals that histological lesions are stable at 2 years, that certain drugs may have an aggravating role and that Ag e has no prognostic value.
12名接受血液透析6个月至3年的患者感染了乙肝表面抗原（AgHBs）阳性肝炎，其中9名患者的e抗原（Ag e）也呈阳性。他们持续携带相同的抗原。从疾病的第6个月开始进行组织学监测，9名患者在1.5至3.5年期间进行了2至4次重复活检，最后3名患者在第8至15个月之间仅进行了一次活检。6名患者的首次活检显示为慢性持续性肝炎（CPH），另外6名患者（5名男性和1名女性）为慢性活动性肝炎（CAH）。后续活检显示，一名接受α-甲基多巴治疗（Ag e +）的患者出现了肝硬化，其他7名患者（4名CPH，包括3名Ag e +；3名CAH，包括2名Ag e +）没有任何变化，最后一名患者病情有所改善。通过对血液透析患者进行重复活检对乙肝进行长期监测发现，组织学病变在2年内是稳定的，某些药物可能具有加重作用，且Ag e没有预后价值。
