Schuler J J, Flanigan D P, Lim L T, Keifer T, Williams L R, Behrend A J
Surgery. 1982 Dec;92(6):1058-67.
It has been suggested that carotid endarterectomy for carotid bifurcation disease may be contraindicated in the presence of carotid siphon lesions. This study was undertaken to assess any difference in stroke rate, mortality, or relief of symptoms in patients with and without such "tandem" lesions following elective carotid endarterectomy. Ninety-one bifurcation endarterectomies were performed in 79 patients. The patients were divided into two groups. Group I (44 patients, 47 endarterectomies) had carotid bifurcation stenosis only; group I (35 patients, 44 endarterectomies) had siphon stenosis plus bifurcation stenosis. All patients in both groups who were symptomatic before operation were relieved of their symptoms. In group I there were no intraoperative or perioperative strokes, four late strokes (8.7%), one operate death (2.1%), and no late deaths. Group II patients had two intraoperative strokes (4.5%), three perioperative strokes (6.8%), two late strokes (5.1%), four operative deaths (9.1%), and three late deaths (7.5%). Eighteen of the 35 patients in group II had a greater degree of carotid siphon stenosis than bifurcation stenosis. In this subgroup, there was one operative stroke (5.6%), only perioperative stroke (5.6%), one late stroke (5.9%), one postoperative death (5.6%), and one late death (5.6%). None of these differences were statistically significant. Relief of symptoms was the same in patients with and without tandem carotid lesions, and there was no significantly increased risk of stroke or death following bifurcation endarterectomy in patients with tandem carotid lesions.
有人提出,对于存在颈动脉虹吸部病变的患者,行颈动脉内膜切除术治疗颈动脉分叉处疾病可能是禁忌的。本研究旨在评估择期颈动脉内膜切除术后,有或无此类“串联”病变的患者在卒中发生率、死亡率或症状缓解方面是否存在差异。对79例患者实施了91次分叉部内膜切除术。患者被分为两组。第一组(44例患者,47次内膜切除术)仅患有颈动脉分叉处狭窄;第二组(35例患者,44次内膜切除术)患有虹吸部狭窄加分叉处狭窄。两组中所有术前有症状的患者症状均得到缓解。第一组术中及围手术期无卒中发生,4例迟发性卒中(8.7%),1例手术死亡(2.1%),无迟发性死亡。第二组患者有2例术中卒中(4.5%),3例围手术期卒中(6.8%),2例迟发性卒中(5.1%),4例手术死亡(9.1%),3例迟发性死亡(7.5%)。第二组35例患者中有18例颈动脉虹吸部狭窄程度大于分叉处狭窄。在该亚组中,有1例手术卒中(5.6%),1例围手术期卒中(5.6%),1例迟发性卒中(5.9%),1例术后死亡(5.6%),1例迟发性死亡(5.6%)。这些差异均无统计学意义。有或无串联颈动脉病变的患者症状缓解情况相同,串联颈动脉病变患者行分叉部内膜切除术后卒中或死亡风险无显著增加。