Altmeyer P, Munz D
Z Hautkr. 1982 Sep 15;57(18):1325-36.
99mTc-HSA-MM proved to be a valuable agent for both bone marrow visualisation and exploration of the phagocytic and proteolytic function of the RES-macrophages in psoriatic patients. 24 psoriatics and 24 normal healthy adults were examined. 18 (75%) of the psoriatics studied demonstrated peripheral extension of the bone marrow space, whereas this phenomenon could not be observed in normal subjects. The phagocytic and proteolytic turnover of 99mTc HSA-MM in liver, spleen and bone marrow was found to be accelerated in 66% (n = 12) of the systemically untreated persons. Six psoriatics treated systemically with aromatic retinoid for a longer period showed 2x a delayed and 4x a normal turnover; three patients with cirrhosis of liver showed in each case a delayed turnover of HSA-MM - Human Serum Albumin-Millimicrospheres.
99mTc-HSA-MM被证明是一种有价值的试剂，可用于银屑病患者的骨髓显像以及网状内皮系统巨噬细胞吞噬和蛋白水解功能的研究。对24例银屑病患者和24名正常健康成年人进行了检查。在研究的银屑病患者中，18例（75%）显示骨髓空间向外周扩展，而正常受试者未观察到这种现象。在66%（n = 12）未经全身治疗的患者中，发现肝脏、脾脏和骨髓中99mTc HSA-MM的吞噬和蛋白水解周转率加快。6例接受芳香维甲酸长期全身治疗的银屑病患者显示，2例周转率延迟，4例周转率正常；3例肝硬化患者的HSA-MM（人血清白蛋白微球）周转率均延迟。
