Heinrich U E, Bolkenius M
Z Kinderchir. 1982 Sep;37(1):20-2. doi: 10.1055/s-2008-1059809.
Hypoplastic development of the phallus renders repair of hypospadias more difficult and very often limits functional and cosmetic results. We therefore tried to simplify surgery and to improve results by perioperative low-dose intramuscular testosterone treatment. 9 children with hypospadias of varying degree were treated with testosterone enantate 25-250 mg x 3 (2 injections at 3 weeks intervals preop. and 1 injection postop). Bone age, growth and phallic development were followed up to 2 years. While there was a reliable degree of phallic growth in most of the boys, in only 3 of the children we observed a slight transitory acceleration of skeletal development, in 7 a transitory increase of growth rate. No signs of virilisation were noted. We believe that in selected cases of hypospadias a short-term low-dose testosterone treatment may be an acceptable means to simplify and improve repair.
阴茎发育不全使尿道下裂修复更为困难，且常常限制功能和外观效果。因此，我们试图通过围手术期低剂量肌内注射睾酮治疗来简化手术并改善治疗效果。9例不同程度尿道下裂患儿接受了25 - 250mg丙酸睾酮×3（术前每隔3周注射2次，术后注射1次）治疗。对骨龄、生长和阴茎发育进行了长达2年的随访。虽然大多数男孩阴茎有可靠程度的生长，但仅3例患儿观察到骨骼发育有轻微短暂加速，7例患儿生长速率有短暂增加。未发现男性化迹象。我们认为，在某些尿道下裂病例中，短期低剂量睾酮治疗可能是简化和改善修复的一种可接受方法。
