Fiorica V, Galloway D C, Males J L, Painton R P, Kem D C
Am J Med Sci. 1982 Nov-Dec;284(3):9-15. doi: 10.1097/00000441-198211000-00002.
Variability in the levels of epinephrine (E) and norepinephrine (NE) in adrenal vein blood is thought to preclude their usefulness in caval sampling studies for localizing abdominal pheochromocytoma. In this study we demonstrate, in three patients, that the fraction of the total catecholamine level in the adrenal effluent represented by E (E fraction) may differentiate the normal adrenal medulla from the gland containing a pheochromocytoma. This observation is additionally supported by calculations of the E fractions, from adrenal venous E and NE reported recently, in three other patients with pheochromocytoma. Our data, combined with those from the literature, yield a mean E fraction, in adrenal vein blood, of 63.8 +/- 11.4 (SD)% for seven normal adrenal medullae, and of 28.5 +/- 4.8% for five glands bearing pheochromocytoma. The use of this parameter for lateralizing adrenal pheochromocytoma is suggested if other procedures are unable to demonstrate the tumor.
肾上腺静脉血中肾上腺素（E）和去甲肾上腺素（NE）水平的变异性被认为使其在用于定位腹部嗜铬细胞瘤的腔静脉采样研究中无法发挥作用。在本研究中，我们在三名患者中证明，由E代表的肾上腺流出物中总儿茶酚胺水平的分数（E分数）可以区分正常肾上腺髓质与含有嗜铬细胞瘤的腺体。最近报道的另外三名嗜铬细胞瘤患者肾上腺静脉E和NE的E分数计算结果进一步支持了这一观察结果。我们的数据与文献中的数据相结合，得出七个正常肾上腺髓质的肾上腺静脉血中E分数的平均值为63.8±11.4（标准差）%，五个患有嗜铬细胞瘤的腺体的E分数平均值为28.5±4.8%。如果其他检查无法显示肿瘤，建议使用该参数来定位肾上腺嗜铬细胞瘤。
