Barie P S, Tahamont M V, Malik A B
Am Rev Respir Dis. 1982 Nov;126(5):904-8. doi: 10.1164/arrd.1982.126.5.904.
We examined the role of granulocytes in the development of increased pulmonary vascular permeability during acute pancreatitis in acute sheep lung lymph preparation. One group of animals was depleted of 95% of circulating granulocytes by injection of hydroxyurea. In this group and in a second group of control animals, acute hemorrhagic pancreatitis was produced by injection of trypsin and sodium taurocholate acid into the pancreas. Pulmonary lymph flow and transvascular protein clearance increased without changes in pulmonary vascular pressures, indicating that acute pancreatitis h ad produced a pulmonary vascular injury. These changes occurred with a decrease in circulating granulocytes. Prior granulocyte depletion prevented the increases in lymph flow and protein clearance produced by pancreatitis, whereas the changes in platelet count, fibrinogen, and peritoneal fluid amylase concentrations were similar in both groups. These findings indicate that circulating granulocytes are necessary for the development of pulmonary vascular injury after acute pancreatitis.
我们在急性绵羊肺淋巴制备模型中研究了粒细胞在急性胰腺炎期间肺血管通透性增加发展过程中的作用。一组动物通过注射羟基脲使循环粒细胞减少95%。在该组动物以及第二组对照动物中，通过向胰腺注射胰蛋白酶和牛磺胆酸钠诱导急性出血性胰腺炎。肺淋巴流量和跨血管蛋白清除率增加，而肺血管压力无变化，表明急性胰腺炎已造成肺血管损伤。这些变化伴随着循环粒细胞数量的减少。预先进行粒细胞清除可防止胰腺炎引起的淋巴流量和蛋白清除率增加，而两组的血小板计数、纤维蛋白原和腹腔液淀粉酶浓度变化相似。这些发现表明，循环粒细胞是急性胰腺炎后肺血管损伤发生所必需的。
