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[一种用于研究抗肿瘤抗生素细胞毒性作用的快速方法的应用]

[Use of an express method in studying the cytotoxic action of antitumor antibiotics].

作者信息

Makukho L V, Volkolupova O P

出版信息

Antibiotiki. 1981 Mar;26(3):130-2.

PMID:7235656
Abstract

The cytostatic effect of some antitumor antibiotics such as carminomycin, olivomycin, bruneomycin, rubomycin C and adriamycin was studied with a rapid method based on measurement of 3H-thymidine and 14C-adenine incorporation into the tumor cells of suspended primary cultures of mouse lymphadenosis NK/Ly. The method is recommended for screening of antitumor antibiotics.

摘要

采用一种基于测量³H-胸腺嘧啶核苷和¹⁴C-腺嘌呤掺入小鼠淋巴腺病NK/Ly悬浮原代培养肿瘤细胞的快速方法,研究了某些抗肿瘤抗生素如洋红霉素、橄榄霉素、棕红霉素、柔红霉素C和阿霉素的细胞生长抑制作用。该方法推荐用于筛选抗肿瘤抗生素。

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