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消炎痛可消除必需脂肪酸对实验性变应性脑脊髓炎的抑制作用。

Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin.

作者信息

Mertin J, Stackpoole A

出版信息

Prostaglandins Med. 1978 Oct;1(4):283-91. doi: 10.1016/0161-4630(78)90047-2.

DOI:10.1016/0161-4630(78)90047-2
PMID:715066
Abstract

Experimental allergic encephalomyelitis in Lewis rats was suppressed by treatment with essential fatty acids (EFA) given perorally. This treatment effect could be abolished by administration of a drug (Indomethacin) known to inhibit biosynthesis of certain prostaglandins from EFA. This observation suggests that the suppressive effect of EFA on cell-mediated immune reactions is brought about by EFA-derived prostaglandins.

摘要

口服必需脂肪酸（EFA）可抑制Lewis大鼠的实验性变应性脑脊髓炎。已知一种能抑制某些前列腺素从EFA生物合成的药物（吲哚美辛）可消除这种治疗效果。该观察结果表明，EFA对细胞介导免疫反应的抑制作用是由EFA衍生的前列腺素引起的。

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Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin.消炎痛可消除必需脂肪酸对实验性变应性脑脊髓炎的抑制作用。
Prostaglandins Med. 1978 Oct;1(4):283-91. doi: 10.1016/0161-4630(78)90047-2.
2
The spleen is required for the suppression of experimental allergic encephalomyelitis by prostaglandin precursors.前列腺素前体抑制实验性变应性脑脊髓炎需要脾脏参与。
Clin Exp Immunol. 1979 Jun;36(3):449-55.
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Cerebral prostaglandin synthesis during the dietary and pathological stresses of essential fatty acid deficiency and experimental allergic encephalomyelitis.在必需脂肪酸缺乏和实验性变应性脑脊髓炎的饮食及病理应激过程中脑内前列腺素的合成
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Incidence and severity of experimental allergic encephalomyelitis and cerebral prostaglandin synthesis in essential fatty acid deficient and aspirin-treated rats.必需脂肪酸缺乏及阿司匹林处理大鼠的实验性变应性脑脊髓炎发病率和严重程度与脑前列腺素合成
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