• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The spleen is required for the suppression of experimental allergic encephalomyelitis by prostaglandin precursors.前列腺素前体抑制实验性变应性脑脊髓炎需要脾脏参与。
Clin Exp Immunol. 1979 Jun;36(3):449-55.
2
Mechanisms of suppression of experimental autoimmune encephalomyelitis by intravenous administration of myelin basic protein: role of regulatory spleen cells.静脉注射髓鞘碱性蛋白抑制实验性自身免疫性脑脊髓炎的机制：调节性脾细胞的作用
Exp Mol Pathol. 2000 Feb;68(1):29-37. doi: 10.1006/exmp.1999.2290.
3
Transfer of allergic encephalomyelitis with spleen cells from donors sensitized with myelin basic protein in incomplete Freund's adjuvant.用髓鞘碱性蛋白在不完全弗氏佐剂中致敏的供体的脾细胞转移过敏性脑脊髓炎。
J Immunol. 1982 Feb;128(2):932-4.
4
Regulation of paralytic experimental allergic encephalomyelitis in rats: susceptibility to active and passive disease reinduction.大鼠麻痹性实验性变应性脑脊髓炎的调节：主动和被动疾病再诱导的易感性
J Immunol. 1981 May;126(5):1857-62.
5
Immunoregulation of passively induced allergic encephalomyelitis.
J Immunol. 1986 Mar 1;136(5):1676-9.
6
Suppression of acute experimental allergic encephalomyelitis in guinea pigs by prior transfer of suboptimal numbers of EAE-effector cells: induction of chronic EAE in whole tissue-sensitized guinea pigs.预先转移次优数量的实验性自身免疫性脑脊髓炎（EAE）效应细胞对豚鼠急性实验性变应性脑脊髓炎的抑制作用：全组织致敏豚鼠慢性EAE的诱导
J Immunol. 1982 Feb;128(2):635-8.
7
Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin.消炎痛可消除必需脂肪酸对实验性变应性脑脊髓炎的抑制作用。
Prostaglandins Med. 1978 Oct;1(4):283-91. doi: 10.1016/0161-4630(78)90047-2.
8
Oral testosterone in male rats and the development of experimental autoimmune encephalomyelitis.雄性大鼠口服睾酮与实验性自身免疫性脑脊髓炎的发展
Neuroimmunomodulation. 2005;12(4):246-54. doi: 10.1159/000085656.
9
Cerebral prostaglandin synthesis during the dietary and pathological stresses of essential fatty acid deficiency and experimental allergic encephalomyelitis.在必需脂肪酸缺乏和实验性变应性脑脊髓炎的饮食及病理应激过程中脑内前列腺素的合成
Lipids. 1978 Jun;13(6):408-14. doi: 10.1007/BF02533710.
10
Autoimmune effector cells. IV. Induction of experimental allergic encephalomyelitis in Lewis rats without adjuvant.自身免疫效应细胞。IV. 无佐剂情况下在刘易斯大鼠中诱导实验性变态反应性脑脊髓炎
J Immunol. 1983 Feb;130(2):732-4.

引用本文的文献

1
The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice.ω-3脂肪酸对fat-1小鼠中枢神经系统再髓鞘化的影响。
BMC Neurosci. 2017 Jan 24;18(1):19. doi: 10.1186/s12868-016-0312-5.
2
The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-beta1) up-regulation and increased prostaglandin E2 (PGE2) production.ω-6脂肪酸在实验性自身免疫性脑脊髓炎（EAE）中与转化生长因子-β1（TGF-β1）上调及前列腺素E2（PGE2）生成增加相关的保护作用。
Clin Exp Immunol. 2000 Dec;122(3):445-52. doi: 10.1046/j.1365-2249.2000.01399.x.
3
Linoleic acid therapy in severe experimental allergic encephalomyelitis in the guinea-pig: suppression by continuous treatment.豚鼠严重实验性变应性脑脊髓炎中的亚油酸疗法：持续治疗的抑制作用
Clin Exp Immunol. 1980 Jun;40(3):523-31.
4
Effect of indomethacin treatment upon actively-induced and transferred experimental allergic encephalomyelitis (EAE) in Lewis rats.吲哚美辛治疗对Lewis大鼠主动诱导和转移的实验性变态反应性脑脊髓炎（EAE）的影响。
Clin Exp Immunol. 1982 Aug;49(2):386-92.
5
Induction of immune responses in vivo with small numbers of veiled (dendritic) cells.利用少量面纱样（树突状）细胞在体内诱导免疫反应。
Proc Natl Acad Sci U S A. 1983 Oct;80(19):6032-5. doi: 10.1073/pnas.80.19.6032.

本文引用的文献

1
Transfer of allergic encephalomyelitis using splenectomized albino rats.使用脾切除白化大鼠进行变应性脑脊髓炎的转移
Proc Soc Exp Biol Med. 1961 Dec;108:768-71. doi: 10.3181/00379727-108-27061.
2
Active suppression of immunoglobulin allotype synthesis. II. Transfer of suppressing factor with spleen cells.免疫球蛋白同种异型合成的主动抑制。II. 抑制因子与脾细胞的转移。
J Exp Med. 1972 May 1;135(5):1163-76. doi: 10.1084/jem.135.5.1163.
3
Double-blind trial of linoleate supplementation of the diet in multiple sclerosis.饮食中补充亚油酸对多发性硬化症的双盲试验。
Br Med J. 1973 Mar 31;1(5856):765-8. doi: 10.1136/bmj.1.5856.765.
4
Recurrent experimental allergic encephalomyelitis in the Lewis rat.Lewis大鼠复发性实验性变应性脑脊髓炎
J Immunol. 1974 Aug;113(2):712-5.
5
Suppression of lymphocyte transformation by 16, (16) dimethyl prostaglandin E2 and unsaturated fatty acids.16,（16）-二甲基前列腺素E2和不饱和脂肪酸对淋巴细胞转化的抑制作用。
Proc Soc Exp Biol Med. 1975 Sep;149(4):1026-8. doi: 10.3181/00379727-149-38949.
6
Specific inhibitory action of polyunsaturated fatty acids on lymphocyte transformation induced by PHA and PPD.多不饱和脂肪酸对PHA和PPD诱导的淋巴细胞转化的特异性抑制作用。
Int Arch Allergy Appl Immunol. 1975;48(2):203-10. doi: 10.1159/000231306.
7
Effect of polyunsaturated fatty acids on skin allograft survival and primary and secondary cytotoxic response in mice.多不饱和脂肪酸对小鼠皮肤同种异体移植存活及初次和二次细胞毒性反应的影响。
Transplantation. 1976 Jan;21(1):1-4. doi: 10.1097/00007890-197601000-00001.
8
Antigen stimulation of prostaglandin synthesis and control of immune responses.抗原刺激对前列腺素合成及免疫反应的调控
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1300-4. doi: 10.1073/pnas.73.4.1300.
9
Suppressor activity of the human spleen and thymus.人类脾脏和胸腺的抑制活性。
Surgery. 1976 Apr;79(4):393-7.
10
Induction of T-cell dependent splenic prostaglandin F2alpha by T-cell dependent antigen.T细胞依赖性抗原诱导T细胞依赖性脾前列腺素F2α的产生。
Biochem Biophys Res Commun. 1975 Sep 2;66(1):425-9. doi: 10.1016/s0006-291x(75)80345-7.

前列腺素前体抑制实验性变应性脑脊髓炎需要脾脏参与。

The spleen is required for the suppression of experimental allergic encephalomyelitis by prostaglandin precursors.

作者信息

Mertin J, Stackpoole A

出版信息

Clin Exp Immunol. 1979 Jun;36(3):449-55.

PMID:487646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537739/
Abstract

In this paper we report a study of the effects of splenectomy on the immunosuppressive action of essential fatty acids (EFA) which is thought to be mediated through prostaglandins (PG) produced in the spleen. Experimental allergic encephalomyelitis (EAE) was induced in normal, splenectomized and sham splenectomized Lewis rats. EFA were administered orally, the animals in the control groups being treated with liquid paraffin. Treatment with EFA significantly suppressed clinical disease in those animals in which EAE was induced by the inoculation of central nervous system material of guinea-pigs or by passive transfer by Con A-stimulated spleen cells. Splenectomy abrogated the suppressive effect of EFA. This observation, together with previous results showing the abrogation of EFA immunosuppression by an inhibitor of the biosynthesis of PG from EFA, led us to postulate a close relationship between EFA, PG and a splenic factor suppressing immunopathological mechanisms in EAE.

摘要

在本文中，我们报告了一项关于脾切除术对必需脂肪酸（EFA）免疫抑制作用影响的研究，据认为该作用是通过脾脏产生的前列腺素（PG）介导的。在正常、脾切除和假脾切除的Lewis大鼠中诱发实验性变应性脑脊髓炎（EAE）。口服给予EFA，对照组动物用液体石蜡治疗。在用豚鼠中枢神经系统物质接种或通过Con A刺激的脾细胞被动转移诱导EAE的动物中，EFA治疗显著抑制了临床疾病。脾切除术消除了EFA的抑制作用。这一观察结果，连同先前显示从EFA生物合成PG的抑制剂消除EFA免疫抑制作用的结果，使我们推测EFA、PG与抑制EAE免疫病理机制的脾脏因子之间存在密切关系。