前列腺素前体抑制实验性变应性脑脊髓炎需要脾脏参与。
The spleen is required for the suppression of experimental allergic encephalomyelitis by prostaglandin precursors.
作者信息
Mertin J, Stackpoole A
出版信息
Clin Exp Immunol. 1979 Jun;36(3):449-55.
In this paper we report a study of the effects of splenectomy on the immunosuppressive action of essential fatty acids (EFA) which is thought to be mediated through prostaglandins (PG) produced in the spleen. Experimental allergic encephalomyelitis (EAE) was induced in normal, splenectomized and sham splenectomized Lewis rats. EFA were administered orally, the animals in the control groups being treated with liquid paraffin. Treatment with EFA significantly suppressed clinical disease in those animals in which EAE was induced by the inoculation of central nervous system material of guinea-pigs or by passive transfer by Con A-stimulated spleen cells. Splenectomy abrogated the suppressive effect of EFA. This observation, together with previous results showing the abrogation of EFA immunosuppression by an inhibitor of the biosynthesis of PG from EFA, led us to postulate a close relationship between EFA, PG and a splenic factor suppressing immunopathological mechanisms in EAE.
在本文中，我们报告了一项关于脾切除术对必需脂肪酸（EFA）免疫抑制作用影响的研究，据认为该作用是通过脾脏产生的前列腺素（PG）介导的。在正常、脾切除和假脾切除的Lewis大鼠中诱发实验性变应性脑脊髓炎（EAE）。口服给予EFA，对照组动物用液体石蜡治疗。在用豚鼠中枢神经系统物质接种或通过Con A刺激的脾细胞被动转移诱导EAE的动物中，EFA治疗显著抑制了临床疾病。脾切除术消除了EFA的抑制作用。这一观察结果，连同先前显示从EFA生物合成PG的抑制剂消除EFA免疫抑制作用的结果，使我们推测EFA、PG与抑制EAE免疫病理机制的脾脏因子之间存在密切关系。
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