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The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions.

作者信息

Hildebrandt A G

出版信息

Biochem Soc Symp. 1972;34:79-102.

PMID:4570969
Abstract
摘要

相似文献

1
The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions.甲吡酮与细胞色素P - 450的结合及其对肝微粒体混合功能氧化反应的抑制作用。
Biochem Soc Symp. 1972;34:79-102.
2
Formation and binding of carbanions by cytochrome P-450 of liver microsomes.
Drug Metab Dispos. 1973 Jan-Feb;1(1):176-83.
3
The role of cytochrome P-450 in the N-oxidation of individual amines.细胞色素P-450在单个胺类N-氧化中的作用。
Drug Metab Dispos. 1973 Jan-Feb;1(1):299-313.
4
Determination of active centers of hepatic microsomal cytochrome P-450 by metyrapone, applying mutual depletion system kinetics.采用相互消耗系统动力学，通过甲吡酮测定肝微粒体细胞色素P-450的活性中心。
Drug Metab Dispos. 1973 Jan-Feb;1(1):194-8.
5
[Role of cytochrome P-450 in mixed function oxidation and metabolism of anesthetics].[细胞色素P-450在麻醉剂的混合功能氧化及代谢中的作用]
Masui. 1974 Feb;23(2):89-98.
6
Proceedings: Kinetics of the binding of carbon monoxide and oxygen to microsomal cytochrome P450 and the influence of substrates.
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7
Partial purification and some spectral properties of hepatic microsomal cytochrome P-450.肝脏微粒体细胞色素P-450的部分纯化及某些光谱特性
Drug Metab Dispos. 1973 Jan-Feb;1(1):6-13.
8
The effect of piperonyl butoxide concentration on the formation of cytochrome P-450 difference spectra in hepatic microsomes from mice.
Mol Pharmacol. 1972 Mar;8(2):204-14.
9
Kinetic experiments on the synergistic effect of NADH on microsomal drug oxidation.
Xenobiotica. 1974 Sep;4(9):549-61. doi: 10.3109/00498257409052096.
10
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.
Biochem Biophys Res Commun. 1974 Sep 9;60(1):440-7. doi: 10.1016/0006-291x(74)90223-x.

引用本文的文献

1
Chromate metabolism in liver microsomes.铬酸盐在肝微粒体中的代谢。
Biol Trace Elem Res. 1979 Mar;1(1):55-62. doi: 10.1007/BF02783843.
2
Studies on the Specificity and Site of Action of alpha-Cyclopropyl-alpha-[p-methoxyphenyl]-5-pyrimidine Methyl Alcohol (Ancymidol), a Plant Growth Regulator.α-环丙基-α-[对甲氧基苯基]-5-嘧啶甲醇（增效醚），一种植物生长调节剂的特异性和作用部位的研究。
Plant Physiol. 1978 Oct;62(4):571-6. doi: 10.1104/pp.62.4.571.
3
5-Hydroxytryptamine is biotransformed by CYP2C9, 2C19 and 2B6 to hydroxylamine, which is converted into nitric oxide.
5-羟色胺经细胞色素P450 2C9、2C19和2B6生物转化为羟胺，后者再转化为一氧化氮。
Br J Pharmacol. 2004 Feb;141(3):407-14. doi: 10.1038/sj.bjp.0705632. Epub 2004 Jan 12.
4
The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the hepatic first pass elimination of propranolol in the pithed rat.氯丙嗪、甲吡酮、丙咪嗪和SKF 525 - A对脊髓麻醉大鼠肝脏中普萘洛尔首过消除的影响。
Br J Pharmacol. 1982 Dec;77(4):667-77. doi: 10.1111/j.1476-5381.1982.tb09345.x.
5
Short-term kinetics of serum adrenal steroids and plasma ACTH after a single dose of metyrapone in man.
J Endocrinol Invest. 1980 Jul-Sep;3(3):229-36. doi: 10.1007/BF03348268.
6
Non-competitive and competitive inhibition of mixed function oxidase in rat liver microsomes by metyrapone.甲吡酮对大鼠肝微粒体中混合功能氧化酶的非竞争性和竞争性抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1973;277(1):27-38. doi: 10.1007/BF00498782.
7
Active centers of microsomal cytochrome P-450 determined with metyrapone by mutural depletion system kinetics.采用甲吡酮通过相互消耗系统动力学测定微粒体细胞色素P-450的活性中心。
Naunyn Schmiedebergs Arch Pharmacol. 1973;277(1):39-52. doi: 10.1007/BF00498783.
8
Metyrapone: an agent for melatonin as well as ACTH and cortisol secretion.甲吡酮：一种影响褪黑素、促肾上腺皮质激素及皮质醇分泌的药物。
J Endocrinol Invest. 1985 Apr;8(2):91-5. doi: 10.1007/BF03350653.
9
Mechanisms of action of lipoxygenase and cytochrome P-450-mono-oxygenase inhibitors in blocking endothelium-dependent vasodilatation.脂氧合酶和细胞色素P-450单加氧酶抑制剂阻断内皮依赖性血管舒张的作用机制。
Br J Pharmacol. 1988 Mar;93(3):569-78. doi: 10.1111/j.1476-5381.1988.tb10312.x.
10
An improved assay for bacterial methane mono-oxygenase: some properties of the enzyme from Methylomonas methanica.一种改进的细菌甲烷单加氧酶检测方法：甲基单胞菌属甲烷菌中该酶的一些特性
Biochem J. 1975 Nov;151(2):459-62. doi: 10.1042/bj1510459.