Abbas A M, Jones R B, Rigby C C, Zaman M M
Curr Med Res Opin. 1982;8(4):260-5. doi: 10.1185/03007998209109776.
Seventy-seven elective or emergency surgical patients were treated with a prophylactic course of netilmicin. Netilmicin (150 mg intramuscularly) was given 1 hour prior to operation and continued 12 hourly until the patient was free of risk of post-operative infection. There was no microbiological or clinical evidence of post-operative infection in general surgical or orthopaedic patients. Netilmicin seems to be less nephrotoxic than other aminoglycosides. Netilmicin serum levels were within expected values. Netilmicin was found to be an effective and well-tolerated antibiotic, and prophylactic treatment shortened the mean patient bed-stay and hence costs incurred.
77例择期或急诊手术患者接受了奈替米星预防性治疗。术前1小时给予奈替米星（150mg肌内注射），之后每12小时重复给药，直至患者无术后感染风险。普通外科或骨科患者术后无微生物学或临床感染证据。奈替米星似乎比其他氨基糖苷类药物肾毒性更小。奈替米星血清水平在预期范围内。结果发现奈替米星是一种有效且耐受性良好的抗生素，预防性治疗缩短了患者平均住院时间，从而降低了费用。
