Savin W M, Davidson D M, Haskell W L
J Appl Physiol Respir Environ Exerc Physiol. 1982 Dec;53(6):1572-5. doi: 10.1152/jappl.1982.53.6.1572.
To assess the contribution of the autonomic nervous system to heart rate recovery following exertion, heart rate was observed after peak treadmill exercise in six men following parasympathetic blockade (PB) with atropine sulfate (0.03 mg/kg), sympathetic blockade (SB) with propranolol hydrochloride (0.20 mg/kg), double blockade (DB) with both drugs, and no drugs (ND). Least-squares analysis of each subject's heart rate (HR) as an exponential function of recovery time (t) was computed for each treatment giving an equation of the form HR = aebt. HRs at rest, peak exercise, and 10 min of recovery, the coefficients a and b, and the least-squares correlation coefficient (r) were compared among treatments by nonparametric analysis of variance and rank-sum multiple comparisons. HR recovered in an exponential manner after dynamic exercise in each subject with each of the treatment modes (P less than 0.01 for each r, mean across all treatments r = 0.94). Coefficients a and b differed the most between PB and SB. At the cessation of exercise the decreases in venous return and the systemic need for cardiac output are accompanied by an exponential HR decline. The exponential character of the cardiodeceleration seen after peak exercise appears to be an intrinsic property of the circulation because it occurred under each experimental condition.
为评估自主神经系统对运动后心率恢复的作用，对6名男性在使用硫酸阿托品（0.03mg/kg）进行副交感神经阻滞（PB）、使用盐酸普萘洛尔（0.20mg/kg）进行交感神经阻滞（SB）、两种药物联合使用进行双重阻滞（DB）以及不使用药物（ND）的情况下，在跑步机运动达到峰值后观察心率。针对每种治疗方法，计算每个受试者心率（HR）作为恢复时间（t）的指数函数的最小二乘法分析，得出形式为HR = aebt的方程。通过非参数方差分析和秩和多重比较，比较各治疗组之间静息心率、运动峰值心率、恢复10分钟时的心率、系数a和b以及最小二乘相关系数（r）。在每种治疗模式下，每个受试者在动态运动后心率均呈指数方式恢复（每种治疗模式下r均小于0.01，所有治疗模式的平均r = 0.94）。系数a和b在PB和SB之间差异最大。运动停止时，静脉回流减少和全身对心输出量的需求下降伴随着心率呈指数下降。运动峰值后出现的心减速的指数特征似乎是循环系统的固有特性，因为它在每种实验条件下均会出现。
