Maciel B C, Gallo L, Marin Neto J A, Lima Filho E C, Martins L E
Clin Sci (Lond). 1986 Oct;71(4):457-60. doi: 10.1042/cs0710457.
The relative contribution of the efferent components of the sympathetic and parasympathetic nervous systems to the heart rate (HR) response to dynamic physical exercise was evaluated in 23 normal males. The dynamic exercise was performed on a bicycle ergometer at work loads of 25, 50 and 100 W, before and after pharmacological blockade with atropine (13 individuals) or propranolol (10 individuals). Parasympathetic blockade significantly depressed the rapid HR response at the beginning of the exercise period at all levels of intensity, whereas sympathetic blockade only affected the slow-response phase (1-4 min), especially at the highest level of effort. The present results suggest that the tachycardia evoked by dynamic exercise is mediated by a biphasic mechanism initially depending on rapid vagal release, which increases progressively with increasing effort. An increased sympathetic activity manifests itself in a more delayed manner, especially at the higher levels of activity. Continuous monitoring of HR during the entire period of activity at different levels of intensity permits the utilization of dynamic exercise as a simple and non-invasive method for the functional evaluation of the two components of the autonomic nervous system of the heart.
在23名正常男性中评估了交感神经系统和副交感神经系统的传出成分对动态体育锻炼心率（HR）反应的相对贡献。在使用阿托品（13人）或普萘洛尔（10人）进行药理阻断前后，在自行车测力计上以25、50和100W的工作负荷进行动态运动。副交感神经阻断在所有强度水平下均显著抑制运动开始时的快速心率反应，而交感神经阻断仅影响慢反应阶段（1-4分钟），尤其是在最高努力水平时。目前的结果表明，动态运动诱发的心动过速由双相机制介导，最初取决于快速迷走神经释放，其随着努力程度的增加而逐渐增加。交感神经活动增加以更延迟的方式表现出来，尤其是在较高活动水平时。在不同强度水平的整个活动期间持续监测心率，允许将动态运动用作一种简单且无创的方法，用于对心脏自主神经系统的两个成分进行功能评估。
