A theoretical examination of the effects of gut wall metabolism, hepatic elimination, and enterohepatic recycling on estimates of bioavailability and of hepatic blood flow.

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作者信息

Pang K S, Gillette J R

出版信息

J Pharmacokinet Biopharm. 1978 Oct;6(5):355-67. doi: 10.1007/BF01062719.

DOI:10.1007/BF01062719

PMID:731406

Abstract

摘要

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A theoretical examination of the effects of gut wall metabolism, hepatic elimination, and enterohepatic recycling on estimates of bioavailability and of hepatic blood flow.

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本文引用的文献

Influence of first-pass effect on availability of drugs on oral administration.首过效应对口服给药时药物可利用度的影响。

J Pharm Sci. 1971 Sep;60(9):1338-40. doi: 10.1002/jps.2600600909.

Hepatic vascular bed.肝血管床

Physiol Rev. 1971 Jan;51(1):23-65. doi: 10.1152/physrev.1971.51.1.23.

Influence of route of administration on drug availability.给药途径对药物可利用性的影响。

J Pharm Sci. 1972 Jan;61(1):70-4. doi: 10.1002/jps.2600610111.

Effects of route of administration and blood flow on hepatic drug elimination.给药途径和血流对肝脏药物消除的影响。

J Pharmacol Exp Ther. 1975 Dec;195(3):424-32.

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance.药物的肝清除率。I. “充分搅拌”模型和“平行管”模型的理论考量。肝血流量、血浆和血细胞结合以及肝细胞酶活性对肝药物清除率的影响。

J Pharmacokinet Biopharm. 1977 Dec;5(6):625-53. doi: 10.1007/BF01059688.

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