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A theoretical examination of the effects of gut wall metabolism, hepatic elimination, and enterohepatic recycling on estimates of bioavailability and of hepatic blood flow.

作者信息

Pang K S, Gillette J R

出版信息

J Pharmacokinet Biopharm. 1978 Oct;6(5):355-67. doi: 10.1007/BF01062719.

DOI:10.1007/BF01062719
PMID:731406
Abstract
摘要

相似文献

1
A theoretical examination of the effects of gut wall metabolism, hepatic elimination, and enterohepatic recycling on estimates of bioavailability and of hepatic blood flow.
J Pharmacokinet Biopharm. 1978 Oct;6(5):355-67. doi: 10.1007/BF01062719.
2
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General treatment of the enterohepatic recirculation of drugs and its influence on the area under the plasma level curves, bioavailability, and clearance.药物肝肠循环的一般处理及其对血浆浓度曲线下面积、生物利用度和清除率的影响。
Pharm Res. 1992 Oct;9(10):1306-13. doi: 10.1023/a:1015861502354.
5
Steroid absorption and enterohepatic recycling.类固醇吸收与肠肝循环。
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6
Theoretical relationships between area under the curve and route of administration of drugs and their precursors for evaluating sites and pathways of metabolism.
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Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow model, and QGut model.述评：生理药代动力学肠道模型中对肠道和全身利用率的流动效应的理论预测：传统模型、分隔流动模型和 QGut 模型。
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Impact of route-dependent phase-II gut metabolism and enterohepatic circulation on the bioavailability and systemic disposition of resveratrol in rats and humans: A comprehensive whole body physiologically-based pharmacokinetic modeling.基于生理学的药物全身药代动力学模型：探讨肠道代谢和肠肝循环对红景天苷在大鼠和人体内生物利用度和全身分布的影响及其与给药途径的相关性。
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Role of gut contents, intestinal wall, and liver on the first pass metabolism and absolute bioavailability of isotretinoin in the dog.肠道内容物、肠壁和肝脏对异维A酸在犬体内首过代谢及绝对生物利用度的作用。
Drug Metab Dispos. 1983 Sep-Oct;11(5):458-62.

引用本文的文献

1
A recirculatory model with enterohepatic circulation by measuring portal and systemic blood concentration difference.一种通过测量门静脉和体循环血液浓度差异来建立肝肠循环的再循环模型。
J Pharmacokinet Pharmacodyn. 2003 Apr;30(2):119-44. doi: 10.1023/a:1024415730100.
2
Metabolite pharmacokinetics: the area under the curve of metabolite and the fractional rate of metabolism of a drug after different routes of administration for renally and hepatically cleared drugs and metabolites.代谢物药代动力学：肾清除和肝清除药物及代谢物经不同给药途径给药后代谢物的曲线下面积和药物代谢分数率。
J Pharmacokinet Biopharm. 1981 Aug;9(4):477-87. doi: 10.1007/BF01060890.
3

本文引用的文献

1
Influence of first-pass effect on availability of drugs on oral administration.首过效应对口服给药时药物可利用度的影响。
J Pharm Sci. 1971 Sep;60(9):1338-40. doi: 10.1002/jps.2600600909.
2
Hepatic vascular bed.肝血管床
Physiol Rev. 1971 Jan;51(1):23-65. doi: 10.1152/physrev.1971.51.1.23.
3
Influence of route of administration on drug availability.给药途径对药物可利用性的影响。
Estimating the fraction reabsorbed in drugs undergoing enterohepatic circulation.
估算经历肠肝循环的药物的重吸收分数。
J Pharmacokinet Biopharm. 1982 Aug;10(4):455-61. doi: 10.1007/BF01065175.
4
A nonlinear physiologic pharmacokinetic model: I. Steady-state.一种非线性生理药代动力学模型：I. 稳态
J Pharmacokinet Biopharm. 1985 Feb;13(1):73-92. doi: 10.1007/BF01073657.
5
A review of metabolite kinetics.代谢物动力学综述。
J Pharmacokinet Biopharm. 1985 Dec;13(6):633-62. doi: 10.1007/BF01058905.
6
Analysis of enterohepatic circulation of cefixime in rat by fast inverse Laplace transform (FILT).通过快速拉普拉斯逆变换（FILT）分析大鼠体内头孢克肟的肠肝循环。
J Pharmacokinet Biopharm. 1990 Dec;18(6):545-59. doi: 10.1007/BF01073938.
7
Pharmacokinetics and bioavailability of diclofenac in the rat.双氯芬酸在大鼠体内的药代动力学和生物利用度
J Pharmacokinet Biopharm. 1991 Dec;19(6):647-65. doi: 10.1007/BF01080872.
8
General treatment of the enterohepatic recirculation of drugs and its influence on the area under the plasma level curves, bioavailability, and clearance.药物肝肠循环的一般处理及其对血浆浓度曲线下面积、生物利用度和清除率的影响。
Pharm Res. 1992 Oct;9(10):1306-13. doi: 10.1023/a:1015861502354.
J Pharm Sci. 1972 Jan;61(1):70-4. doi: 10.1002/jps.2600610111.
4
Effects of route of administration and blood flow on hepatic drug elimination.给药途径和血流对肝脏药物消除的影响。
J Pharmacol Exp Ther. 1975 Dec;195(3):424-32.
5
Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance.药物的肝清除率。I. “充分搅拌”模型和“平行管”模型的理论考量。肝血流量、血浆和血细胞结合以及肝细胞酶活性对肝药物清除率的影响。
J Pharmacokinet Biopharm. 1977 Dec;5(6):625-53. doi: 10.1007/BF01059688.