Greenough W T, West R W, DeVoogd T J
Science. 1978 Dec 8;202(4372):1096-8. doi: 10.1126/science.715459.
The relative frequency of appearance of discontinuities in the postsynaptic thickening, or perforations in the subsynaptic plate, increased with age and experience. Rats reared from weaning in complex or social environments had a significantly higher proportion of occipital cortical synapses with perforations than did rats reared in isolation. In addition, the relative frequency of these perforations more than tripled between 10 and 60 days of age. Shifts in the frequency of perforations can occur independently of changes in the size of synpases. This result suggests a new potential mechanism of synaptic plasticity.
突触后增厚中不连续现象的相对出现频率，或突触下板中的穿孔，随年龄和经验增加。从断奶起就在复杂或社交环境中饲养的大鼠，其枕叶皮质有穿孔的突触比例显著高于单独饲养的大鼠。此外，这些穿孔的相对频率在10至60日龄之间增加了两倍多。穿孔频率的变化可以独立于突触大小的变化而发生。这一结果提示了一种新的突触可塑性潜在机制。
