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癫痫患者的记忆损害:苯巴比妥浓度的选择性影响。

Memory impairment in epileptic patients: selective effects of phenobarbital concentration.

作者信息

MacLeod C M, Dekabian A S, Hunt E

出版信息

Science. 1978 Dec 8;202(4372):1102-4. doi: 10.1126/science.715461.

DOI:10.1126/science.715461
PMID:715461
Abstract

Nineteen epileptic patients were tested first under medium (week 1) and then under high (week 2) therapeutic levels of phenobarbital. Relative to response times of 20 controls with equivalent practice but without medication, response times of patients in a short-term memory scanning task were strikingly slowed during week 2. However, increased phenobarbital did not slow responses in a task requiring access to information in long-term memory.

摘要

19名癫痫患者首先在苯巴比妥中等治疗水平(第1周)下接受测试,然后在高治疗水平(第2周)下接受测试。相对于20名进行了同等训练但未用药的对照组的反应时间,患者在短期记忆扫描任务中的反应时间在第2周显著减慢。然而,苯巴比妥剂量增加并未减慢在一项需要获取长期记忆信息的任务中的反应速度。

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引用本文的文献

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[Formula: see text]Differences in memory functioning between children with attention-deficit/hyperactivity disorder and/or focal epilepsy.注意缺陷多动障碍和/或局灶性癫痫患儿记忆功能的差异。
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2
Reducing the number of anticonvulsant drugs taken by severely retarded epileptic patients.减少严重智障癫痫患者所服用的抗癫痫药物的数量。
Can Fam Physician. 1984 Apr;30:819-22.
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Behav Genet. 2010 May;40(3):315-26. doi: 10.1007/s10519-009-9315-7. Epub 2009 Nov 29.
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