Joyce D A, Beilin L J, Vandongen R, Davidson L
Life Sci. 1982 Nov 29;31(22):2513-7. doi: 10.1016/0024-3205(82)90758-5.
Simultaneously drawn arterial and forearm venous levels of free and sulfate conjugated epinephrine and norepinephrine were measured in 8 subjects in order to study the role of skeletal muscle in catecholamine sulfation. A sensitive radioenzymatic assay was used. The average free epinephrine level was 46% lower in venous than in arterial blood (p less than 0.023) while average sulfated epinephrine level was 37% higher (p less than 0.016). These findings suggest that epinephrine sulfation is occurring in the forearm, most likely in skeletal muscle. The mean venous free norepinephrine level was 21% higher than the mean arterial level (p less than 0.055) presumably reflecting release from sympathetic nerve terminals. No evidence of norepinephrine sulfation or deconjugation in skeletal muscle was found.
为了研究骨骼肌在儿茶酚胺硫酸化中的作用，对8名受试者同时采集动脉血和前臂静脉血，测量游离及硫酸结合型肾上腺素和去甲肾上腺素的水平。采用了一种灵敏的放射酶分析法。静脉血中游离肾上腺素的平均水平比动脉血低46%（p<0.023），而硫酸化肾上腺素的平均水平则高37%（p<0.016）。这些发现表明，前臂，很可能是骨骼肌中正在发生肾上腺素硫酸化。静脉血中游离去甲肾上腺素的平均水平比动脉血平均水平高21%（p<0.055），这可能反映了交感神经末梢的释放。未发现骨骼肌中有去甲肾上腺素硫酸化或去结合的证据。
