Smirnova O V, Smirnov A N
Probl Endokrinol (Mosk). 1982 Nov-Dec;28(6):35-8.
Several properties of estradiol (E2)-binding cytosol macromolecules in the liver of females with cholecystitis and of males with hepatic cirrhosis were studied by means of comparatively delicate methods of free- and bound hormone separation. E2-binding macromolecules with Stokes' radius of approximately 5 nm were found in the hepatic samples under study, formed with E2 complexes, similar to estrogen receptors, according to hormonal specificity of affinity and stability. Protein, similar to a specific estrogen-binding protein of the rat and guinea pig liver, was not found in the preparations examined.
采用较为精细的游离激素与结合激素分离方法，对患有胆囊炎的雌性和患有肝硬化的雄性肝脏中雌二醇（E2）结合胞质大分子的若干特性进行了研究。在所研究的肝脏样本中发现了斯托克斯半径约为5纳米的E2结合大分子，根据亲和力和稳定性的激素特异性，它们与E2形成的复合物类似于雌激素受体。在所检测的制剂中未发现类似于大鼠和豚鼠肝脏中特异性雌激素结合蛋白的蛋白质。
