Pandey V K, Parmeswaran M, Soman S D, Dacosta H J
Sci Total Environ. 1982 Nov;25(3):277-85. doi: 10.1016/0048-9697(82)90020-1.
In a grave illness the homeostasis of some elements may be upset either by the disease process per se, or by the therapy adopted. Patients with pyogenic, viral and tubercular meningo-encephalitis were targets of interest. 108 subjects' serum and cerebrospinal fluid (CSF) compartments were assayed for magnesium, calcium, zinc and copper, by atomic absorption spectrometry. Results showed that the serum pool was more intensely altered than the CSF pool in the case of magnesium and calcium but the reverse occurred for zinc and copper. No organism-dependent change was noted, but comatosed patients were the worst effected. These findings are discussed with respect to the relative brain and CSF content of each element and the patho-physiology which could alter the compartments studied.
在严重疾病中，某些元素的体内平衡可能会因疾病本身的进程或所采用的治疗方法而被打破。化脓性、病毒性和结核性脑膜脑炎患者是研究对象。采用原子吸收光谱法对108名受试者的血清和脑脊液（CSF）样本进行镁、钙、锌和铜含量检测。结果显示，就镁和钙而言，血清中的变化比脑脊液更为明显，但锌和铜的情况则相反。未观察到因病原体不同而产生的变化，但昏迷患者受影响最为严重。结合每种元素在大脑和脑脊液中的相对含量以及可能改变所研究样本区室的病理生理学对这些发现进行了讨论。
